SCHEMBL185165

SCHEMBL185165

Cc1cc(C)c(S(=O)(=O)O)cc1N=Nc1cc(S(=O)(=O)O)c2ccccc2c1O.[Na].[Na]

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 2/20 0.60
SENP2 Q9HC62 5/20 0.55
SENP1 Q9P0U3 4/20 0.55
SUMO2 P61956 4/20 0.55
SUMO1 P63165 4/20 0.55
SENP7 Q9BQF6 4/20 0.55
SENP3 Q9H4L4 2/20 0.55
PHLPP2 Q6ZVD8 1/20 0.54
TP53 P04637 1/20 0.53
CREBBP Q92793 1/20 0.53
CYP1A2 P05177 2/20 0.52
THRB P10828 2/20 0.51
APP P05067 2/20 0.51
MAPT P10636 2/20 0.51
SNCA P37840 2/20 0.51
MPL P40238 3/20 0.49
HPGD P15428 2/20 0.49
CTRC Q99895 1/20 0.49
MEN1 O00255 1/20 0.49
ALDH1A1 P00352 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1136824 0.99 BRD4 (0.62) BRD4SENP2SENP1SUMO2SUMO1
SCHEMBL692673 0.99 BRD4 (0.62) BRD4SENP2SENP1SUMO2SUMO1
SCHEMBL6126114 0.99 BRD4 (0.62) BRD4SENP2SENP1SUMO2SUMO1
SCHEMBL4811412 0.97 BRD4 (0.60) BRD4SENP2SENP1SUMO2SUMO1
SCHEMBL185164 0.97 BRD4 (0.60) BRD4SENP2SENP1SUMO2SUMO1
SCHEMBL3188346 0.90 THRB (0.67) BRD4SENP2SENP1SUMO2SUMO1
SCHEMBL4841813 0.90 THRB (0.67) BRD4SENP2SENP1SUMO2SUMO1
SCHEMBL21433094 0.86 BRD4 (0.54) BRD4SENP2SENP1SUMO2SUMO1
SCHEMBL23787780 0.85 PHLPP2 (0.67) SENP2SENP1SUMO2SUMO1SENP7
SCHEMBL31222680 0.84 CTRB1 (0.66) BRD4SENP2SENP1SUMO2SUMO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2930126-B1 Fashionable aerosol dye HENKEL AG & CO KGAA (DE) 2019-10-09 EP claimed
US-10259946-B1 Sealing agents, methods of making and uses thereof James Hardie Technology Limited (IE) 2019-04-16 US disclosed
US-9173829-B2 Compositions for dyeing keratin fibers HENKEL AG & CO. KGAA (DE) 2015-11-03 US disclosed
US-9161898-B2 Compositions for colouring keratin fibres HENKEL AG & CO. KGAA (DE) 2015-10-20 US disclosed
US-20140298592-A1 COMPOSITIONS FOR DYEING KERATIN FIBERS HENKEL AG & CO. KGAA (DE) 2014-10-09 US disclosed
US-20140290690-A1 COMPOSITIONS FOR COLOURING KERATIN FIBRES HENKEL AG & CO. KGAA (DE) 2014-10-02 US disclosed
US-8632612-B2 Compositions for dyeing keratin fibers SEGETIS, INC. (US) 2014-01-21 US disclosed
US-20130156716-A1 COMPOSITIONS FOR DYEING KERATIN FIBERS SEGETIS, INC. (US) 2013-06-20 US disclosed
EP-2103299-B1 Oxidizing hair colourant compositions PROCTER & GAMBLE (US) 2013-02-27 EP disclosed
EP-1455740-B1 PROCESS FOR PREPARATION OF HAIR TREATMENT COMPOSITION COMPRISING COMPOSITE PARTICLES OF CLAY AND CHARGED ORGANIC MOLECULE UNILEVER PLC (GB) 2012-01-04 EP disclosed
US-6558433-B2 Oxidation hair dye WELLA AG (DE) 2003-05-06 US disclosed
US-20030041392-A1 Process for making 1,4-diamino-2-methoxymethylbenzene and salts thereof and compositions and methods for dyeing keratin fibers containing same Wella GmbH (DE) 2003-03-06 US disclosed
US-20020189031-A1 Use of salts for improving the absorption qualities of anionic direct dyes WELLA AKTIENGESELLSCHAFT (DE) 2002-12-19 US disclosed
US-6485529-B1 Agent and method for coloring fibers WELLA AKTIENGESELLSCHAFT (DE) 2002-11-26 US disclosed
US-6461390-B1 Process for making 2-aminomethyl-1, 4-diaminobenzene and its salts and compositions and methods for dyeing keratin fibers using same WELLA AKTIENGESELLSCHAFT (DE) 2002-10-08 US disclosed
US-6379400-B1 DYEING FIBERS, SOLVENT OF WATER OR ALCOHOL AND NITROANILINE DYE WELLA AKTIENGESELLSCHAFT (DE) 2002-04-30 US disclosed
US-6361571-B1 USING TAUTOMERIC NONOXIDATIVE DYES AND POLYMETHINE DYES WELLA AKTIENGESELLSCHAFT (DE) 2002-03-26 US disclosed
US-6231622-B1 MIXTURES; BLUE COLOR WELLA AKTIENGESELLSCHAFT (DE) 2001-05-15 US disclosed
US-6171347-B1 REMOVAL OF HAIR COLOR TO BE WORN FOR ONLY A SHORT PERIOD OF TIME UNDER MILD, GENTLE CONDITIONS BY USING A COMBINATION OF A SUITABLE REDUCTONE, SUCH AS ASCORBIC ACID, AND/OR A THIOL AND/OR A SULFITE WELLA AKTIENGESELLSCHAFT (DE) 2001-01-09 US disclosed
US-6106579-A MIXTURE OF OXOCARBOXYLIC ACID AND REDUCING AGENT WELLA AKTIENGESELLSCHAFT (DE) 2000-08-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140290690-A1 COMPOSITIONS FOR COLOURING KERATIN FIBRES KRT18, DSG1, PKN1 BRD4 2398/4885SENP2 3440/4885SENP1 4060/4885
US-20140298592-A1 COMPOSITIONS FOR DYEING KERATIN FIBERS KRT18, PKN3, IK BRD4 1363/4885SENP2 3855/4885SENP1 3744/4885
US-20130156716-A1 COMPOSITIONS FOR DYEING KERATIN FIBERS KRT18, KRTCAP2, JUP BRD4 1921/4885SENP2 2807/4885SENP1 2858/4885
US-20030041392-A1 Process for making 1,4-diamino-2-methoxymethylbenzene and salts thereof and compositions and methods for dyeing keratin fibers containing same KRT18, SCNN1B, DDAH1 BRD4 1219/4885SENP2 4461/4885SENP1 4241/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.