Sugi Predict

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SCHEMBL18535540

SCHEMBL18535540

CCCCCc1ccc(-c2cc3ccc(O)cc3oc2=O)c(C(F)(F)F)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ESR2 Q92731 2/20 0.45
▸ AKR1B10 O60218 4/20 0.45
▸ AKR1B1 P15121 4/20 0.45
▸ MIF P14174 9/20 0.45
▸ MEN1 O00255 3/20 0.45
▸ KMT2A Q03164 3/20 0.45
▸ GLA P06280 2/20 0.45
▸ RAB9A P51151 2/20 0.45
▸ KDM4E B2RXH2 1/20 0.45
▸ ALDH1A1 P00352 1/20 0.45
▸ POLB P06746 1/20 0.45
▸ GAA P10253 1/20 0.45
▸ HPGD P15428 1/20 0.45
▸ NPSR1 Q6W5P4 1/20 0.45
▸ TDP1 Q9NUW8 1/20 0.45
▸ PTGS1 P23219 1/20 0.44
▸ NPC1 O15118 2/20 0.44
▸ AKR1A1 P14550 2/20 0.43
▸ CBR1 P16152 2/20 0.43
▸ AKR1C4 P17516 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30534173 0.88 CYP19A1 (0.41) AKR1B10AKR1B1MEN1KMT2AKDM4E
SCHEMBL20473384 0.88 CYP19A1 (0.41) AKR1B10AKR1B1MEN1KMT2AKDM4E
SCHEMBL28988825 0.87 CYP19A1 (0.39) MEN1KMT2AKDM4EALDH1A1POLB
SCHEMBL18535717 0.86 TERT (0.45) ESR2MEN1KMT2AGLARAB9A
SCHEMBL22245718 0.86 ALOX5 (0.44) AKR1B10AKR1B1KDM4EALDH1A1PTGS1
SCHEMBL23713483 0.86 CYP19A1 (0.40) AKR1B10AKR1B1MEN1KMT2AKDM4E
SCHEMBL23713512 0.86 NPC1 (0.47) MIFMEN1KMT2AGLARAB9A
SCHEMBL21524255 0.85 CYP19A1 (0.38) AKR1B10AKR1B1MEN1KMT2AKDM4E
SCHEMBL18583397 0.85 CYP19A1 (0.38) ESR2AKR1B10AKR1B1MIFMEN1
SCHEMBL18535599 0.85 MAOB (0.43) MEN1KMT2AGLARAB9AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4327779-A2 SYSTEM AND METHOD AMO Ireland (IE) 2024-02-28 — — EP disclosed
EP-3958788-B1 SYSTEM AND METHOD AMO Ireland (IE) 2023-11-22 — — EP disclosed
US-11702396-B2 Hydrophobic compounds for optically active devices Johnson & Johnson Surgical Vision, Inc. (US) 2023-07-18 — — US disclosed
US-11702396-B2 Hydrophobic compounds for optically active devices Johnson & Johnson Surgical Vision, Inc. (US) 2023-07-18 — — US disclosed
CN-110300747-B Double-type compound for optical active device 爱尔兰眼力健公司 2023-03-28 — — CN disclosed
EP-3728339-B1 COMPOSITION FOR OPHTHALMOLOGICAL PRODUCTS AMO Ireland (IE) 2022-07-06 — — EP disclosed
US-11359031-B2 Composition for ophthalmological products Johnson & Johnson Surgical Vision, Inc. (US) 2022-06-14 — — US disclosed
US-20210363122-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2021-11-25 — — US disclosed
US-11078177-B2 Compounds for optically active devices MERCK PATENT GMBH (DE) 2021-08-03 — — US disclosed
US-11040990-B2 Compounds containing Si atoms for optically active devices MERCK PATENT GMBH (DE) 2021-06-22 — — US disclosed
EP-3583101-B1 BIS-COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2020-10-28 — — EP disclosed
US-20200332041-A1 COMPOSITION FOR OPHTHALMOLOGICAL PRODUCTS MERCK PATENT GMBH (DE) 2020-10-22 — — US disclosed
US-20200062739-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2020-02-27 — — US disclosed
US-20200062739-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2020-02-27 — — US disclosed
US-10457658-B2 Compounds for optically active devices MERCK PATENT GMBH (DE) 2019-10-29 — — US disclosed
EP-3502147-A1 COMPOSITION FOR OPHTHALMOLOGICAL PRODUCTS Merck Patent GmbH (DE) 2019-06-26 — — EP disclosed
WO-2018149850-A1 BIS-COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2018-08-23 — — WO disclosed
EP-3363794-A1 BIS-COMPOUNDS FOR OPTICALLY ACTIVE DEVICES Merck Patent GmbH (DE) 2018-08-22 — — EP disclosed
WO-2017032442-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2017-03-02 — — WO disclosed
EP-3133065-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES Merck Patent GmbH (DE) 2017-02-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210363122-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES PDE6C, ALDH1A2, PDE6A ESR2 3444/4885AKR1B10 2120/4885AKR1B1 2740/4885
US-11702396-B2 Hydrophobic compounds for optically active devices UACA, CRYZ, TRPA1 ESR2 3189/4885AKR1B10 3673/4885AKR1B1 3990/4885
US-10457658-B2 Compounds for optically active devices PDE6C, ALDH1A2, PDE6A ESR2 3444/4885AKR1B10 2120/4885AKR1B1 2740/4885
US-20200062739-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES PDE6C, PDE6A, PDE6D ESR2 3107/4885AKR1B10 2903/4885AKR1B1 3290/4885
US-11040990-B2 Compounds containing Si atoms for optically active devices UACA, EYA3, PDE6C ESR2 2212/4885AKR1B10 4648/4885AKR1B1 4756/4885
US-11078177-B2 Compounds for optically active devices PDE6C, ALDH1A2, PDE6A ESR2 3444/4885AKR1B10 2120/4885AKR1B1 2740/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.