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SCHEMBL18535548

SCHEMBL18535548

CCCCCc1ccc(-c2cc3ccc(O)cc3oc2=O)c(CC)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ESR2 Q92731 1/20 0.49
▸ GLA P06280 2/20 0.48
▸ AKR1B10 O60218 3/20 0.48
▸ AKR1B1 P15121 3/20 0.48
▸ MEN1 O00255 3/20 0.48
▸ KMT2A Q03164 3/20 0.48
▸ MIF P14174 10/20 0.48
▸ PTGS1 P23219 1/20 0.48
▸ NPC1 O15118 2/20 0.47
▸ AKR1A1 P14550 1/20 0.47
▸ CBR1 P16152 1/20 0.47
▸ AKR1C4 P17516 1/20 0.47
▸ AKR1C3 P42330 1/20 0.47
▸ AKR1C2 P52895 1/20 0.47
▸ AKR1C1 Q04828 1/20 0.47
▸ RAB9A P51151 2/20 0.46
▸ RXFP1 Q9HBX9 1/20 0.46
▸ SIRT3 Q9NTG7 1/20 0.46
▸ ERAP1 Q9NZ08 1/20 0.46
▸ POLB P06746 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24595591 0.91 ESR2 (0.49) ESR2GLAAKR1B10AKR1B1MEN1
SCHEMBL18535562 0.88 MEN1 (0.57) ESR2GLAMEN1KMT2AMIF
SCHEMBL18535465 0.86 CYP19A1 (0.41) GLAAKR1B10AKR1B1MEN1KMT2A
SCHEMBL21735206 0.86 ALOX5 (0.47) AKR1B10AKR1B1MEN1KMT2APTGS1
SCHEMBL21761551 0.86 MIF (0.61) ESR2AKR1B10AKR1B1MEN1KMT2A
SCHEMBL18535540 0.85 ESR2 (0.45) ESR2GLAAKR1B10AKR1B1MEN1
SCHEMBL18535577 0.85 ESR2 (0.45) ESR2GLAAKR1B10AKR1B1MEN1
SCHEMBL18523587 0.85 ESR2 (0.67) ESR2GLAAKR1B10AKR1B1MEN1
SCHEMBL18535678 0.84 NPC1 (0.51) GLAMEN1KMT2AMIFNPC1
SCHEMBL23316820 0.84 GLA (0.55) GLAMEN1KMT2ANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3958788-B1 SYSTEM AND METHOD AMO Ireland (IE) 2023-11-22 — — EP disclosed
CN-110382473-B Hydrophobic compounds for optically active devices 爱尔兰眼力健公司 2023-08-15 — — CN disclosed
US-11702396-B2 Hydrophobic compounds for optically active devices Johnson & Johnson Surgical Vision, Inc. (US) 2023-07-18 — — US disclosed
US-11702396-B2 Hydrophobic compounds for optically active devices Johnson & Johnson Surgical Vision, Inc. (US) 2023-07-18 — — US disclosed
US-11702396-B2 Hydrophobic compounds for optically active devices Johnson & Johnson Surgical Vision, Inc. (US) 2023-07-18 — — US disclosed
CN-110300747-B Double-type compound for optical active device 爱尔兰眼力健公司 2023-03-28 — — CN disclosed
US-20210363122-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2021-11-25 — — US disclosed
US-11078177-B2 Compounds for optically active devices MERCK PATENT GMBH (DE) 2021-08-03 — — US disclosed
US-11040990-B2 Compounds containing Si atoms for optically active devices MERCK PATENT GMBH (DE) 2021-06-22 — — US disclosed
US-11001576-B2 Compounds for optically active devices MERCK PATENT GMBH (DE) 2021-05-11 — — US disclosed
US-10457658-B2 Compounds for optically active devices MERCK PATENT GMBH (DE) 2019-10-29 — — US disclosed
CN-110382473-A Hydrophobic compound for optical activity device 默克专利股份有限公司 2019-10-25 — — CN disclosed
CN-110300747-A Dimorphism compound for optical activity device 默克专利股份有限公司 2019-10-01 — — CN disclosed
EP-3502147-A1 COMPOSITION FOR OPHTHALMOLOGICAL PRODUCTS Merck Patent GmbH (DE) 2019-06-26 — — EP disclosed
WO-2018149850-A1 BIS-COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2018-08-23 — — WO disclosed
WO-2018149855-A1 HYDROPHOBIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2018-08-23 — — WO disclosed
EP-3363793-A1 HYDROPHOBIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES Merck Patent GmbH (DE) 2018-08-22 — — EP disclosed
EP-3363794-A1 BIS-COMPOUNDS FOR OPTICALLY ACTIVE DEVICES Merck Patent GmbH (DE) 2018-08-22 — — EP disclosed
WO-2017032442-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2017-03-02 — — WO disclosed
EP-3133065-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES Merck Patent GmbH (DE) 2017-02-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210363122-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES PDE6C, ALDH1A2, PDE6A ESR2 3444/4885GLA 315/4885AKR1B10 2120/4885
US-11702396-B2 Hydrophobic compounds for optically active devices UACA, CRYZ, TRPA1 ESR2 3189/4885GLA 963/4885AKR1B10 3673/4885
US-10457658-B2 Compounds for optically active devices PDE6C, ALDH1A2, PDE6A ESR2 3444/4885GLA 315/4885AKR1B10 2120/4885
US-11040990-B2 Compounds containing Si atoms for optically active devices UACA, EYA3, PDE6C ESR2 2212/4885GLA 1045/4885AKR1B10 4648/4885
US-11078177-B2 Compounds for optically active devices PDE6C, ALDH1A2, PDE6A ESR2 3444/4885GLA 315/4885AKR1B10 2120/4885
US-11001576-B2 Compounds for optically active devices PDE6C, PDE6A, PDE6D ESR2 3107/4885GLA 247/4885AKR1B10 2903/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.