Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 5/20 | 0.51 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | ITGAV | P06756 | 1/20 | 0.51 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18576765 | 0.71 | HSD17B10 (0.36) | L3MBTL1 | |
| SCHEMBL18927575 | 0.70 | RIPK1 (0.59) | — | |
| SCHEMBL15704276 | 0.69 | RAB9A (0.48) | ITGB1ITGB3ITGAVITGA5HTT | |
| SCHEMBL18573595 | 0.69 | LMNA (0.55) | — | |
| SCHEMBL11987662 | 0.67 | NPSR1 (0.76) | ITGB1ITGA4ITGB3ITGAVITGA5 | |
| SCHEMBL23139723 | 0.67 | RIPK1 (0.43) | — | |
| SCHEMBL5763695 | 0.67 | ITGB1 (0.79) | ITGB1ITGA4ITGB3ITGAVITGA5 | |
| SCHEMBL18536665 | 0.67 | ITGB1 (0.41) | ITGB1ITGA4ITGB3ITGAVITGA5 | |
| SCHEMBL11987663 | 0.66 | LMNA (0.64) | ITGB1ITGA4ITGB3ITGAVITGA5 | |
| SCHEMBL12704221 | 0.65 | HSD17B10 (0.38) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170860-B9 | BENZIMIDAZOLE DERIVATIVES | PFIZER (US) | 2017-02-22 | — | — | EP | disclosed |