SCHEMBL1853908

SCHEMBL1853908

O=C1CSc2c(Br)cccc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIM1 P11309 1/20 0.39
CSNK1A1 P48729 1/20 0.39
CDK5 Q00535 1/20 0.39
ROCK1 Q13464 1/20 0.39
DYRK1A Q13627 1/20 0.39
LRRK2 Q5S007 1/20 0.39
CLK4 Q9HAZ1 1/20 0.39
DYRK1B Q9Y463 1/20 0.39
PARP10 Q53GL7 1/20 0.37
PARP11 Q9NR21 1/20 0.37
ACHE P22303 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA7 P43166 1/20 0.35
CA9 Q16790 1/20 0.35
IDO1 P14902 2/20 0.34
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
CDC25B P30305 1/20 0.34
AKT1 P31749 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30908525 1.00 PIM1 (0.39) PIM1CSNK1A1CDK5ROCK1DYRK1A
SCHEMBL7502 0.81 PARP10 (0.39) PIM1CSNK1A1CDK5ROCK1DYRK1A
SCHEMBL4404550 0.76 MEN1 (0.50) PARP10PARP11ACHECA1CA2
SCHEMBL18162627 0.76 NOTUM (0.48) PIM1ACHECA1CA2CA7
SCHEMBL254906 0.76 MAOA (0.47) ACHECA1CA2CA7CA9
SCHEMBL9171936 0.76 MAPT (0.41) ACHEIDO1MEN1KMT2AS100A4
Hydrochloric Acid SCHEMBL10513970 0.74 MAPT (0.40) ACHEIDO1MEN1KMT2AS100A4
SCHEMBL15039690 0.73 ACHE (0.33) ACHEMEN1KMT2AS100A4ALDH1A1
SCHEMBL20022731 0.72 CES1 (0.41) MEN1KMT2AALDH1A1
SCHEMBL30714317 0.71 CDK5 (0.46) PIM1CSNK1A1CDK5ROCK1DYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024074611-A1 PRMT5 INHIBITORS Ryvu Therapeutics S.A. (PL) 2024-04-11 WO disclosed
US-10361377-B2 Condensed cyclic compound and organic light emitting device including the same SAMSUNG SDI CO., LTD. (KR) 2019-07-23 US disclosed
US-20160308143-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO., LTD. (KR) 2016-10-20 US disclosed
US-20160308143-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO., LTD. (KR) 2016-10-20 US disclosed
US-20160308143-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO., LTD. (KR) 2016-10-20 US disclosed
WO-2015108301-A1 FUSED RING COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME 삼성에스디아이 주식회사 2015-07-23 WO disclosed
EP-2323978-A1 AMIDE COMPOUND Takeda Pharmaceutical Company Limited (JP) 2011-05-25 EP disclosed
WO-2010018874-A1 AMIDE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-02-18 WO disclosed
US-20100041891-A1 AMIDE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-02-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160308143-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE INCLUDING THE SAME CRY1, CRY2, CCNE2 PIM1 3117/4885CSNK1A1 2747/4885CDK5 75/4885
US-20100041891-A1 AMIDE COMPOUND GPR52, GPR132, NR5A2 PIM1 3452/4885CSNK1A1 1256/4885CDK5 3927/4885
US-10361377-B2 Condensed cyclic compound and organic light emitting device including the same CRY1, CRY2, CCNE2 PIM1 3117/4885CSNK1A1 2747/4885CDK5 75/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.