Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20571789 | 0.83 | KDM4E (0.47) | MAPTKDM4ENPC1ALDH1A1MEN1 | |
| SCHEMBL348041 | 0.81 | PTGS2 (0.50) | TLR8MAPTPTGS2NPC1RAB9A | |
| SCHEMBL20571944 | 0.80 | ALDH1A1 (0.44) | MAPTKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL16519472 | 0.78 | PTGS2 (0.51) | TLR8MAPTPTGS2NPC1RAB9A | |
| SCHEMBL2333890 | 0.77 | HTR1A (0.47) | MAPTKDM4E | |
| SCHEMBL27540870 | 0.77 | PTGS2 (0.44) | TLR8MAPTKDM4EPTGS2NPC1 | |
| SCHEMBL8908139 | 0.77 | HTR1A (0.47) | MAPTKDM4E | |
| SCHEMBL18541888 | 0.76 | ALDH1A1 (0.55) | TLR8MAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL2607673 | 0.75 | TLR8 (0.50) | TLR8MAPTPTGS2NPC1RAB9A | |
| SCHEMBL6461783 | 0.75 | PTGS2 (0.39) | TLR8MAPTPTGS2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170050931-A1 | INHIBITORS OF RPN11 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050931-A1 | INHIBITORS OF RPN11 | POLR2A, RPP30, RPIA | TLR8 4707/4885MAPT 1647/4885KDM4E 3279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.