Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18548747 | 0.75 | TLR8 (0.44) | PTGS2SMN1; SMN2LMNANPSR1TLR8 | |
| SCHEMBL3874057 | 0.72 | TLR8 (0.49) | PTGS2SMN1; SMN2LMNANPSR1TLR8 | |
| SCHEMBL348041 | 0.70 | PTGS2 (0.50) | PTGS2SMN1; SMN2LMNANPSR1TLR8 | |
| SCHEMBL18758015 | 0.70 | PTGS2 (0.49) | PTGS2LMNANPSR1TLR8CYSLTR2 | |
| SCHEMBL30417186 | 0.70 | PTGS2 (0.49) | PTGS2LMNANPSR1TLR8CYSLTR2 | |
| SCHEMBL20334907 | 0.69 | HTR1A (0.40) | SMN1; SMN2LMNANPSR1TLR8S1PR2 | |
| SCHEMBL25738323 | 0.69 | PTGS2 (0.50) | PTGS2SMN1; SMN2LMNANPSR1TLR8 | |
| SCHEMBL5316461 | 0.69 | PTGS2 (0.50) | PTGS2SMN1; SMN2LMNANPSR1TLR8 | |
| SCHEMBL5579342 | 0.69 | NPC1 (0.49) | SMN1; SMN2LMNANPC1RAB9AEGFR | |
| SCHEMBL12694249 | 0.68 | MEN1 (0.45) | SMN1; SMN2LMNANPSR1S1PR2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050267136-A1 | Method of inhibiting dihydrofolate reductase; screening assay for the identification of novel therapeutics and their cellular targets | MCMASTER UNIVERSITY (CA) | 2005-12-01 | — | — | US | disclosed |
| WO-2004069255-A2 | USE OF QUINAZOLINE DERIVATIVES OR OTHER COMPOUNDS FOR INHIBITING DIHYDROFOLATE REDUXTASE; SCREENING ASSAY FOR THE IDENTIFICATION OF NOVEL THERAPEUTICS AND THEIR CELLULAR TARGETS | MCMASTER UNIVERSITY (CA) | 2004-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267136-A1 | Method of inhibiting dihydrofolate reductase; screening assay for the identification of novel therapeutics and their cellular targets | DHFR, DHODH, DPYD | PTGS2 2098/4885SMN1; SMN2 4102/4885LMNA 4620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.