Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.46 |
| ▸ | GAA | P10253 | 7/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | ME2 | P23368 | 2/20 | 0.46 |
| ▸ | ME1 | P48163 | 2/20 | 0.46 |
| ▸ | ME3 | Q16798 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.46 |
| ▸ | GFER | P55789 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20075898 | 0.89 | ALDH1A1 (0.52) | MAPTGAANCF1ME2ME1 | |
| SCHEMBL30230328 | 0.86 | MAPT (0.49) | MAPTGAANCF1ME2ME1 | |
| SCHEMBL20323922 | 0.81 | ALDH1A1 (0.51) | MAPTGAAME2ME1ME3 | |
| SCHEMBL21026182 | 0.77 | ME2 (0.49) | MAPTGAAME2ME1ME3 | |
| SCHEMBL16026436 | 0.76 | NCF1 (0.57) | MAPTGAANCF1ME2ME1 | |
| SCHEMBL18591763 | 0.76 | MAPT (0.47) | MAPTGAAME2ME1ME3 | |
| SCHEMBL23664609 | 0.74 | SMN1; SMN2 (0.45) | MAPTGAAME2ME1ME3 | |
| SCHEMBL27399979 | 0.73 | NCF1 (0.48) | NCF1KDM4ESMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL27980498 | 0.73 | SMN1; SMN2 (0.68) | MAPTNCF1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL16043662 | 0.72 | MAPT (0.53) | MAPTGAANCF1ME2ME1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017030814-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BROMODOMAIN-CONTAINING PROTEINS | Arvinas, Inc. (US) | 2017-02-23 | — | — | WO | disclosed |