Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | GAA | P10253 | 6/20 | 0.43 |
| ▸ | ME2 | P23368 | 1/20 | 0.42 |
| ▸ | ME1 | P48163 | 1/20 | 0.42 |
| ▸ | ME3 | Q16798 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18591763 | 0.87 | MAPT (0.47) | SMN1; SMN2ALDH1A1LMNAMAPTGAA | |
| SCHEMBL23664607 | 0.81 | NCF1 (0.40) | ALDH1A1MAPTGAAHSD17B10 | |
| SCHEMBL24856050 | 0.81 | MAPT (0.43) | SMN1; SMN2ALDH1A1LMNAMAPTGAA | |
| SCHEMBL21026182 | 0.77 | ME2 (0.49) | SMN1; SMN2ALDH1A1LMNAMAPTGAA | |
| SCHEMBL22965356 | 0.76 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1LMNAMAPTGAA | |
| SCHEMBL20075898 | 0.75 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1LMNAMAPTGAA | |
| SCHEMBL18551215 | 0.74 | MAPT (0.46) | SMN1; SMN2ALDH1A1LMNAMAPTGAA | |
| SCHEMBL20323922 | 0.74 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1LMNAMAPTGAA | |
| SCHEMBL30230328 | 0.72 | MAPT (0.49) | SMN1; SMN2ALDH1A1LMNAMAPTGAA | |
| SCHEMBL18592219 | 0.70 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1LMNAMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210220475-A1 | EGFR PROTEOLYSIS TARGETING CHIMERIC MOLECULES AND ASSOCIATED METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210220475-A1 | EGFR PROTEOLYSIS TARGETING CHIMERIC MOLECULES AND ASSOCIATED METHODS OF USE | TBK1, EGFR, CBL | SMN1; SMN2 4046/4885ALDH1A1 4031/4885LMNA 4148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.