SCHEMBL18566653

SCHEMBL18566653

OC(c1ccccc1)(c1ccccc1)c1cc(Br)c2ccccc2c1-c1cccc2c1oc1ccccc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX5 P09917 3/20 0.43
▸ GGPS1 O95749 1/20 0.39
▸ MEN1 O00255 1/20 0.37
▸ CYP2C19 P33261 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ HDAC8 Q9BY41 1/20 0.36
▸ PRKDC P78527 5/20 0.34
▸ CDC14B O60729 3/20 0.34
▸ CDC14A Q9UNH5 3/20 0.34
▸ ESR2 Q92731 1/20 0.34
▸ PTGES2 Q9H7Z7 1/20 0.33
▸ ATM Q13315 1/20 0.33
▸ DYRK1A Q13627 1/20 0.32
▸ PIK3CD O00329 1/20 0.31
▸ PIK3CB P42338 1/20 0.31
▸ AHR P35869 1/20 0.31
▸ PTPRC P08575 1/20 0.31
▸ PTPRF P10586 1/20 0.31
▸ PTPN1 P18031 1/20 0.31
▸ PTPRA P18433 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22004949 0.87 ALOX5 (0.39) ALOX5GGPS1MEN1CYP2C19KMT2A
SCHEMBL4552061 0.79 ALOX5 (0.51) ALOX5GGPS1MEN1CYP2C19KMT2A
SCHEMBL21102390 0.79 ALOX5 (0.49) ALOX5GGPS1MEN1CYP2C19KMT2A
SCHEMBL16614125 0.79 ALOX5 (0.46) ALOX5GGPS1MEN1CYP2C19KMT2A
SCHEMBL18364037 0.78 ALOX5 (0.42) ALOX5GGPS1MEN1CYP2C19KMT2A
SCHEMBL18566635 0.78 ALOX5 (0.47) ALOX5GGPS1MEN1KMT2AHDAC8
SCHEMBL17814813 0.76 CYP2C19 (0.54) ALOX5GGPS1MEN1CYP2C19KMT2A
SCHEMBL21102409 0.76 ALOX5 (0.48) ALOX5GGPS1MEN1CYP2C19KMT2A
SCHEMBL17307494 0.75 ALOX5 (0.47) ALOX5GGPS1MEN1CYP2C19KMT2A
SCHEMBL10109059 0.75 ALOX5 (0.50) ALOX5GGPS1MEN1CYP2C19KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11683980-B2 Condensed fluorene derivative comprising heterocyclic ring SFC CO., LTD. (KR) 2023-06-20 — — US disclosed
US-11683980-B2 Condensed fluorene derivative comprising heterocyclic ring SFC CO., LTD. (KR) 2023-06-20 — — US disclosed
US-11672172-B2 Heterocyclic compound comprising aromatic amine group and organic light-emitting diode including the same SFC CO., LTD. (KR) 2023-06-06 — — US disclosed
US-11672172-B2 Heterocyclic compound comprising aromatic amine group and organic light-emitting diode including the same SFC CO., LTD. (KR) 2023-06-06 — — US disclosed
EP-4116297-A1 CONDENSED FLUORENE DERIVATIVE COMPRISING HETEROCYCLIC RING SFC Co., Ltd. (KR) 2023-01-11 — — EP disclosed
US-20180019430-A1 Organic light-emitting diode with high efficiency SFC CO., LTD. (KR) 2018-01-18 — — US disclosed
US-20170342318-A1 ORGANIC LIGHT-EMITTING DIODE WITH HIGH EFFICIENCY AND LONG LIFETIME SFC CO., LTD. (KR) 2017-11-30 — — US disclosed
US-20170342318-A1 ORGANIC LIGHT-EMITTING DIODE WITH HIGH EFFICIENCY AND LONG LIFETIME SFC CO., LTD. (KR) 2017-11-30 — — US disclosed
US-20170222155-A1 CONDENSED FLUORENE DERIVATIVE COMPRISING HETEROCYCLIC RING SFC CO., LTD. (KR) 2017-08-03 — — US disclosed
US-20170222155-A1 CONDENSED FLUORENE DERIVATIVE COMPRISING HETEROCYCLIC RING SFC CO., LTD. (KR) 2017-08-03 — — US disclosed
EP-3176158-A2 CONDENSED FLUORENE DERIVATIVE COMPRISING HETERO RING SFC Co., Ltd. (KR) 2017-06-07 — — EP disclosed
US-20170062729-A1 HETEROCYCLIC COMPOUND COMPRISING AROMATIC AMINE GROUP AND ORGANIC LIGHT-EMITTING DIODE INCLUDING THE SAME SFC CO., LTD. (KR) 2017-03-02 — — US disclosed
US-20170062729-A1 HETEROCYCLIC COMPOUND COMPRISING AROMATIC AMINE GROUP AND ORGANIC LIGHT-EMITTING DIODE INCLUDING THE SAME SFC CO., LTD. (KR) 2017-03-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170222155-A1 CONDENSED FLUORENE DERIVATIVE COMPRISING HETEROCYCLIC RING CCNE2, INF2, AFF4 ALOX5 862/4885GGPS1 944/4885MEN1 481/4885
US-11683980-B2 Condensed fluorene derivative comprising heterocyclic ring CCNE2, INF2, AFF4 ALOX5 862/4885GGPS1 944/4885MEN1 481/4885
US-20180019430-A1 Organic light-emitting diode with high efficiency CYBA, CYP1A1, CYP1B1 ALOX5 400/4885GGPS1 1110/4885MEN1 2722/4885
US-20170342318-A1 ORGANIC LIGHT-EMITTING DIODE WITH HIGH EFFICIENCY AND LONG LIFETIME CRY1, CRY2, ALDH1A2 ALOX5 326/4885GGPS1 2990/4885MEN1 1126/4885
US-20170062729-A1 HETEROCYCLIC COMPOUND COMPRISING AROMATIC AMINE GROUP AND ORGANIC LIGHT-EMITTING DIODE INCLUDING THE SAME DDC, TYR, AOC2 ALOX5 763/4885GGPS1 1828/4885MEN1 1488/4885
US-11672172-B2 Heterocyclic compound comprising aromatic amine group and organic light-emitting diode including the same DDC, TYR, AOC2 ALOX5 763/4885GGPS1 1828/4885MEN1 1488/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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