Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 10/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21640161 | 0.82 | OPRL1 (0.39) | OPRM1OPRL1OPRK1OPRD1CYP2D6 | |
| SCHEMBL18765288 | 0.79 | OPRD1 (0.44) | OPRD1CCR5 | |
| SCHEMBL21641112 | 0.79 | OGA (0.41) | OGAOPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL18390055 | 0.78 | OGA (0.44) | OGACYP2D6HRH1KCNH2 | |
| SCHEMBL21640831 | 0.77 | F2 (0.42) | ADORA3SLC6A3CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21641087 | 0.77 | OPRD1 (0.46) | OPRD1L3MBTL1CCR5 | |
| SCHEMBL18764813 | 0.77 | OPRD1 (0.49) | OPRD1CYP2D6CCR5CYP3A4CYP2C9 | |
| SCHEMBL21640779 | 0.77 | OGA (0.49) | OGACYP2D6CCR5CYP3A4CYP2C9 | |
| SCHEMBL21640616 | 0.77 | OGA (0.49) | OGAOPRD1CCR5CYP3A4CYP2C9 | |
| SCHEMBL18556116 | 0.75 | OPRM1 (0.40) | OPRM1OPRL1OPRK1OPRD1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11066399-B2 | Ferroportin inhibitors | VIFOR (INTERNATIONAL) AG (CH) | 2021-07-20 | — | — | US | disclosed |
| US-20210139472-A1 | Novel Ferroportin Inhibitors | VIFOR (INTERNATIONAL) AG (CH) | 2021-05-13 | — | — | US | disclosed |
| US-10738041-B2 | Ferroportin inhibitors | VIFOR (INTERNATIONAL) AG (CH) | 2020-08-11 | — | — | US | disclosed |
| CN-107922434-B | EZH2 inhibitors | 伊莱利利公司 | 2020-06-19 | — | — | CN | disclosed |
| EP-3341379-B1 | INHIBITORS OF EZH2 | LILLY CO ELI (US) | 2019-10-09 | — | — | EP | disclosed |
| EP-3341379-B1 | INHIBITORS OF EZH2 | LILLY CO ELI (US) | 2019-10-09 | — | — | EP | disclosed |
| US-9718838-B2 | Inhibitors of EZH2 | ELI LILLY AND COMPANY (US) | 2017-08-01 | — | — | US | disclosed |
| US-9718838-B2 | Inhibitors of EZH2 | ELI LILLY AND COMPANY (US) | 2017-08-01 | — | — | US | disclosed |
| US-9718838-B2 | Inhibitors of EZH2 | ELI LILLY AND COMPANY (US) | 2017-08-01 | — | — | US | disclosed |
| US-20170066780-A1 | INHIBITORS OF EZH2 | ELI LILLY AND COMPANY | 2017-03-09 | — | — | US | disclosed |
| US-20170066780-A1 | INHIBITORS OF EZH2 | ELI LILLY AND COMPANY | 2017-03-09 | — | — | US | disclosed |
| US-20170066780-A1 | INHIBITORS OF EZH2 | ELI LILLY AND COMPANY | 2017-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139472-A1 | Novel Ferroportin Inhibitors | HAMP, SLC40A1, HMOX1 | OGA 4732/4885OPRM1 1931/4885OPRL1 2754/4885 |
| US-10738041-B2 | Ferroportin inhibitors | SLC40A1, HAMP, TFRC | OGA 3644/4885OPRM1 2835/4885OPRL1 3497/4885 |
| US-11066399-B2 | Ferroportin inhibitors | HAMP, SLC40A1, FTH1 | OGA 4662/4885OPRM1 1593/4885OPRL1 2671/4885 |
| US-20170066780-A1 | INHIBITORS OF EZH2 | EZH2, BMI1, EZH1 | OGA 3862/4885OPRM1 4639/4885OPRL1 4844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.