Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ASPH | Q12797 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | LIPE | Q05469 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28941091 | 0.82 | KIF11 (0.47) | KMT2AMAPK1KDM4EUSP2 | |
| SCHEMBL16712250 | 0.80 | SMN1; SMN2 (0.34) | L3MBTL1HPGDGLAALDH1A1KDM4E | |
| SCHEMBL25591675 | 0.74 | ALDH1A1 (0.33) | KMT2AALDH1A1 | |
| SCHEMBL10655208 | 0.74 | ALOX15 (0.37) | P2RX7KMT2AALDH1A1 | |
| SCHEMBL185449 | 0.74 | ALDH1A1 (0.33) | HPGDGLAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7020112 | 0.74 | ALDH1A1 (0.33) | HPGDGLAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL185620 | 0.72 | LMNA (0.35) | HPGDGLAKMT2AALDH1A1KDM4E | |
| SCHEMBL186013 | 0.72 | L3MBTL1 (0.49) | L3MBTL1ASPHHPGDALDH1A1KDM4E | |
| SCHEMBL186176 | 0.72 | HDAC1 (0.42) | HPGDGLAKMT2AALDH1A1KDM4E | |
| SCHEMBL2291068 | 0.72 | CA1 (0.35) | ASPH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |