Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883802 | 1.00 | ALDH1A1 (0.56) | ALDH1A1CRHBPCRHR2PTPN1PTPN6 | |
| SCHEMBL29522015 | 0.88 | KLK7 (0.49) | ALDH1A1CRHBPCRHR2GAARORC | |
| SCHEMBL13125989 | 0.86 | LMNA (0.43) | ALDH1A1CRHBPCRHR2GAARORC | |
| SCHEMBL6715547 | 0.81 | CYP1A2 (0.44) | ALDH1A1SMN1; SMN2LMNATSHRRAB9A | |
| SCHEMBL26393799 | 0.80 | MMP13 (0.42) | ALDH1A1GAAMTOR | |
| SCHEMBL27132340 | 0.78 | MTOR (0.49) | ALDH1A1GAASMN1; SMN2MTORLMNA | |
| SCHEMBL13883806 | 0.78 | ALDH1A1 (0.58) | ALDH1A1CRHBPCRHR2PTPN1PTPN6 | |
| SCHEMBL1098257 | 0.78 | ROCK2 (0.58) | ALDH1A1 | |
| SCHEMBL1098258 | 0.78 | ROCK2 (0.58) | ALDH1A1 | |
| SCHEMBL6715886 | 0.78 | TSHR (0.50) | ALDH1A1GAASMN1; SMN2TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101143-A1 | Compounds Having Activity in Increasing Ion Transport by Mutant-CFTR and Uses Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2012-04-26 | — | — | US | disclosed |
| US-7939558-B2 | Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-05-10 | — | — | US | disclosed |
| US-20080319008-A1 | Compounds Having Activity in Increasing Ion Transport by Mutant-Cftr and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-25 | — | — | US | disclosed |
| EP-1765347-A4 | COMPOUNDS HAVING ACTIVITY IN INCREASING ION TRANSPORT BY MUTANT-CFTR AND USES THEREOF | UNIV CALIFORNIA (US) | 2008-10-01 | — | — | EP | disclosed |
| EP-1765347-A2 | COMPOUNDS HAVING ACTIVITY IN INCREASING ION TRANSPORT BY MUTANT-CFTR AND USES THEREOF | The Regents of the University of California (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005120497-A2 | COMPOUNDS HAVING ACTIVITY IN INCREASING ION TRANSPORT BY MUTANT-CFTR AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319008-A1 | Compounds Having Activity in Increasing Ion Transport by Mutant-Cftr and Uses Thereof | CFTR, ABCC9, SLC26A4 | ALDH1A1 2700/4885CRHBP 4552/4885CRHR2 4759/4885 |
| US-20120101143-A1 | Compounds Having Activity in Increasing Ion Transport by Mutant-CFTR and Uses Thereof | CFTR, ABCC9, ABCB11 | ALDH1A1 2646/4885CRHBP 4599/4885CRHR2 4792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.