SCHEMBL1864386

SCHEMBL1864386

O=Cc1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1Cl

nearest known ligand 0.35

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.35
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
RECQL P46063 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1695053 0.89 CA1 (0.32) CA1CA2RECQL
SCHEMBL19723103 0.89 PDE3B (0.31)
SCHEMBL2529132 0.86
SCHEMBL2529133 0.86
SCHEMBL19723063 0.86 USP2 (0.31)
SCHEMBL3121312 0.85 RECQL (0.34) TDP1CA1CA2RECQL
SCHEMBL1610490 0.85 NISCH (0.37) CA1CA2RECQL
SCHEMBL1609340 0.83 CYP3A4 (0.36) CA1CA2RECQL
SCHEMBL112195 0.83 CA1 (0.32) CA1CA2RECQL
SCHEMBL1864604 0.83 RECQL (0.34) CA1CA2RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2382196-B1 IMINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS BASF SE (DE) 2015-08-12 EP disclosed
US-8722673-B2 Imine compounds for combating invertebrate pests BASF SE (DE) 2014-05-13 US disclosed
US-8633134-B2 Substituted amidine compounds for combating animal pests BASF SE (DE) 2014-01-21 US disclosed
US-8242283-B2 Isoxazoline compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2012-08-14 US disclosed
EP-2382196-A2 IMINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS BASF SE (DE) 2011-11-02 EP disclosed
EP-2382195-A1 SUBSTITUTED AMIDINE COMPOUNDS FOR COMBATING ANIMAL PESTS BASF SE (DE) 2011-11-02 EP disclosed
US-20110263603-A1 Imine Compounds for Combating Invertebrate Pests BASF SE (DE) 2011-10-27 US disclosed
US-20110257011-A1 Substituted Amidine Compounds for Combating Animal Pests BASF SE (US) 2011-10-20 US disclosed
US-20110172414-A1 ISOXAZOLINE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-07-14 US disclosed
US-7947715-B2 Isoxazoline compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-05-24 US disclosed
WO-2010072602-A1 SUBSTITUTED AMIDINE COMPOUNDS FOR COMBATING ANIMAL PESTS BASF SE (DE) 2010-07-01 WO disclosed
WO-2010072781-A2 IMINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS BASF SE (DE) 2010-07-01 WO disclosed
EP-1997813-B1 SUBSTITUTED ISOXAZOLINE COMPOUND AND PEST CONTROL AGENT NISSAN CHEMICAL IND LTD (JP) 2010-05-05 EP disclosed
US-20090156643-A1 Substituted isoxazoline compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2009-06-18 US disclosed
EP-1997813-A1 SUBSTITUTED ISOXAZOLINE COMPOUND AND PEST CONTROL AGENT Nissan Chemical Industries, Ltd. (JP) 2008-12-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110263603-A1 Imine Compounds for Combating Invertebrate Pests INMT, PNMT, PIR TDP1 2196/4885CA1 4820/4885CA2 4729/4885
US-20110172414-A1 ISOXAZOLINE COMPOUND AND PESTICIDE HCRTR1, HAX1, CHRM1 TDP1 2765/4885CA1 200/4885CA2 93/4885
US-20090156643-A1 Substituted isoxazoline compound and pesticide HCRTR1, CBR1, CHRM1 TDP1 2907/4885CA1 208/4885CA2 133/4885
US-20110257011-A1 Substituted Amidine Compounds for Combating Animal Pests C5, C3AR1, C1S TDP1 1350/4885CA1 2108/4885CA2 2539/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.