Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 8/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654657 | 0.91 | KDM4E (0.40) | KDM4ERAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL18654777 | 0.89 | FYN (0.39) | KDM4ERAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL18654724 | 0.88 | F11 (0.42) | ADORA2AFYNTP53ALDH1A1HSD17B10 | |
| SCHEMBL18655138 | 0.86 | DYRK1A (0.51) | FYN | |
| SCHEMBL18655239 | 0.82 | CSNK1D (0.38) | ADORA2AMAPTALDH1A1 | |
| SCHEMBL14897642 | 0.80 | RAB9A (0.42) | KDM4ERAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL18654986 | 0.80 | MAPT (0.43) | KDM4ESMN1; SMN2FYNMAPTTP53 | |
| SCHEMBL18654415 | 0.79 | TP53 (0.36) | TP53 | |
| SCHEMBL18654742 | 0.79 | RIPK1 (0.40) | FYN | |
| SCHEMBL14896966 | 0.78 | ADORA2A (0.42) | KDM4ERAB9ANPC1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |