SCHEMBL186881

SCHEMBL186881

c1ccc(-c2cnn(-c3ccc(-n4ncc(-c5ccccc5)n4)cc3)n2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.51
HSD17B10 Q99714 2/20 0.51
P2RX7 Q99572 2/20 0.47
KMT2A Q03164 4/20 0.42
NPC1 O15118 4/20 0.42
RAB9A P51151 4/20 0.42
MEN1 O00255 3/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
HPGD P15428 3/20 0.40
GRM5 P41594 2/20 0.40
MAPK1 P28482 2/20 0.39
USP2 O75604 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ALDH1A1 P00352 2/20 0.37
MAPT P10636 2/20 0.37
PKM P14618 1/20 0.37
ABCG2 Q9UNQ0 1/20 0.37
IDO1 P14902 1/20 0.36
METAP2 P50579 1/20 0.36
KEAP1 Q14145 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17279823 0.96 KDM4E (0.56) KDM4EHSD17B10P2RX7KMT2ANPC1
SCHEMBL10766985 0.89 KDM4E (0.44) KDM4EHSD17B10P2RX7KMT2ANPC1
SCHEMBL11682761 0.88 KDM4E (0.43) KDM4EHSD17B10P2RX7KMT2ANPC1
SCHEMBL11125994 0.88 KDM4E (0.43) KDM4EHSD17B10P2RX7KMT2ANPC1
SCHEMBL6395530 0.88 KDM4E (0.43) KDM4EHSD17B10P2RX7KMT2ANPC1
SCHEMBL28444044 0.87 HTT (0.54) KDM4EHSD17B10NPC1RAB9ASMN1; SMN2
SCHEMBL11540373 0.87 KDM4E (0.42) KDM4EHSD17B10P2RX7KMT2ANPC1
SCHEMBL5710307 0.86 GRM5 (0.48) KDM4EHSD17B10P2RX7KMT2ANPC1
SCHEMBL11499348 0.84 KDM4E (0.43) KDM4EHSD17B10P2RX7KMT2ARAB9A
SCHEMBL11499347 0.84 KDM4E (0.43) KDM4EHSD17B10P2RX7KMT2ARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 289 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11968893-B2 Electroluminescent device UDC IRELAND LIMITED (IE) 2024-04-23 US disclosed
US-20220216422-A1 Electroluminescent Device UDC IRELAND LTD (IE) 2022-07-07 US disclosed
US-11345686-B2 Aromatic amine derivative, and organic electroluminescent element IDEMITSU KOSAN CO., LTD. (JP) 2022-05-31 US disclosed
EP-2315502-B1 Electroluminescent device UDC IRELAND LTD (IE) 2020-10-14 EP disclosed
US-10454038-B2 Delayed-fluorescence material and organic electroluminescence element using same KYULUX, INC. (JP) 2019-10-22 US disclosed
US-20190237675-A1 AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE UTILIZING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2019-08-01 US disclosed
US-20190177306-A1 AROMATIC AMINE DERIVATIVE, AND ORGANIC ELECTROLUMINESCENT ELEMENT IDEMITSU KOSAN CO., LTD. (JP) 2019-06-13 US disclosed
US-10312452-B2 Aromatic amine derivative and organic electroluminescence device utilizing the same IDEMITSU KOSAN CO., LTD. (JP) 2019-06-04 US disclosed
US-10246441-B2 Aromatic amine derivative, and organic electroluminescent element IDEMITSU KOSAN CO., LTD. (JP) 2019-04-02 US disclosed
EP-2733762-B1 ORGANIC ELECTROLUMINESCENCE ELEMENT AND COMPOUND USED THEREIN KYULUX INC (JP) 2018-11-28 EP disclosed
US-6280859-B1 AROMATIC ELECTROLUMINESCENT MATERIAL OR NONSUBSTITUTED HETEROAROMATIC GROUP OR DIVALENT GROUP TOYO INK MANUFACTURING CO., LTD. (JP) 2001-08-28 US disclosed
EP-0786926-B1 Light-emitting material for organo-electroluminescence device and organo-electroluminescence devive for which the light-emitting material is adapted TOYO INK MFG CO (JP) 2001-08-22 EP disclosed
US-6245449-B1 LIGHT EMITTER LAYERS OR ORGANIC COMPOUNDS, THIN LAYERS AND ELECTRODES, ANODES AND CATHODES TOYO INK MANUFACTURING CO., LTD. (JP) 2001-06-12 US disclosed
EP-1061112-A1 ORGANIC ELECTROLUMINESCENT ELEMENT IDEMITSU KOSAN COMPANY LIMITED (JP) 2000-12-20 EP disclosed
US-6150042-A ELECTROLUMINESCENCE DEVICE WITH HOLE INJECTING MATERIAL HAVING GOOD DURABILITY BEING A TRIPHENYLENE STRUCTURE OF GIVEN FORMULA HAVING MULTIPLE ETHER, SULFIDE, AND/OR AMINE SUBSTITUTIONS TOYO INK MANUFACTURING CO., LTD. (JP) 2000-11-21 US disclosed
EP-0965629-A1 Compound for organic electroluminescence device and organic electroluminescence device TOYO INK MFG. CO., LTD. (JP) 1999-12-22 EP disclosed
EP-0934992-A1 Light-emitting material for organo-electroluminescence device and organic electroluminescence device TOYO INK MANUFACTURING CO., LTD. (JP) 1999-08-11 EP disclosed
EP-0866110-A1 Light-emitting material for organo-electroluminescence device and organic electroluminescence device TOYO INK MANUFACTURING CO., LTD. (JP) 1998-09-23 EP disclosed
EP-0847228-A2 Material for organoelectroluminescence device and use thereof TOYO INK MANUFACTURING CO., LTD. (JP) 1998-06-10 EP disclosed
EP-0786926-A2 Light-emitting material for organo-electroluminescence device and organo-electroluminescence devive for which the light-emitting material is adapted TOYO INK MANUFACTURING CO., LTD. (JP) 1997-07-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10312452-B2 Aromatic amine derivative and organic electroluminescence device utilizing the same TYR, OCIAD2, MAOA KDM4E 375/4885HSD17B10 2059/4885P2RX7 1760/4885
US-10246441-B2 Aromatic amine derivative, and organic electroluminescent element MAOB, MAOA, NAT1 KDM4E 433/4885HSD17B10 1889/4885P2RX7 3783/4885
US-20190177306-A1 AROMATIC AMINE DERIVATIVE, AND ORGANIC ELECTROLUMINESCENT ELEMENT TYR, LEF1, EFNA1 KDM4E 191/4885HSD17B10 3041/4885P2RX7 2648/4885
US-20220216422-A1 Electroluminescent Device PNPO, ODC1, AXL KDM4E 1312/4885HSD17B10 3539/4885P2RX7 125/4885
US-10454038-B2 Delayed-fluorescence material and organic electroluminescence element using same HNRNPF, RABL6, SRSF6 KDM4E 2926/4885HSD17B10 4293/4885P2RX7 2486/4885
US-11345686-B2 Aromatic amine derivative, and organic electroluminescent element TYR, LEF1, EFNA1 KDM4E 191/4885HSD17B10 3041/4885P2RX7 2648/4885
US-11968893-B2 Electroluminescent device PNPO, ODC1, AXL KDM4E 1312/4885HSD17B10 3539/4885P2RX7 125/4885
US-20190237675-A1 AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE UTILIZING THE SAME TYR, NLRP1, NLRP3 KDM4E 511/4885HSD17B10 1353/4885P2RX7 1086/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.