Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 5/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.32 |
| ▸ | FGR | P09769 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12718595 | 0.82 | HTR2A (0.38) | MAOAMAOBALDH1A1 | |
| SCHEMBL4488117 | 0.77 | MAOA (0.53) | MAOAMAOBTSHRCES2ALDH1A1 | |
| SCHEMBL29137360 | 0.77 | PBRM1 (0.39) | MAOAMAOBCYP3A4CES2PARP1 | |
| SCHEMBL4496694 | 0.77 | MAOA (0.34) | MAOAMAOBCES2PARP1ALDH1A1 | |
| SCHEMBL4496746 | 0.77 | PBRM1 (0.39) | MAOAMAOBTSHRRECQL | |
| SCHEMBL23963013 | 0.77 | ADORA2A (0.37) | ADORA2APTPRCMAOAMAOBDPP4 | |
| SCHEMBL17671008 | 0.77 | MAOA (0.34) | MAOAMAOBCES2PARP1HSPA1A | |
| SCHEMBL12714846 | 0.77 | CES2 (0.46) | ADORA2APTPRCMAOADPP4TSHR | |
| SCHEMBL12714868 | 0.77 | ADORA2A (0.38) | ADORA2APTPRCMAOADPP4CYP3A4 | |
| SCHEMBL1868789 | 0.72 | S100A4 (0.47) | PTPRCMAOATSHRALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011054874-A1 | METHOD FOR THE PREPARATION OF 2-AMINO-6-ETHYLBENZOIC ACID | ACTIVE BIOTECH AB (SE) | 2011-05-12 | — | — | WO | claimed |
| EP-2316818-A1 | Method for the preparation of 2-amino-6-ethylbenzoic acid | Active Biotech AB (SE) | 2011-05-04 | — | — | EP | claimed |
| CN-117327058-A | Synthesis method of 7- [ (4, 6-dimethyl-2-pyrimidinyl) thio ] -3-methyl-1 (3H) -isopropyl furanone | 顺毅南通化工有限公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-116675678-A | Synthesis method of pyriftalid | 顺毅南通化工有限公司 | 2023-09-01 | — | — | CN | disclosed |
| EP-3204374-B1 | ISOINDOLINE DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2019-04-03 | — | — | EP | disclosed |
| EP-3204374-B1 | ISOINDOLINE DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2019-04-03 | — | — | EP | disclosed |
| US-9975873-B2 | Isoindoline derivatives | UCB BIOPHARMA SPRL (BE) | 2018-05-22 | — | — | US | disclosed |
| US-9975873-B2 | Isoindoline derivatives | UCB BIOPHARMA SPRL (BE) | 2018-05-22 | — | — | US | disclosed |
| US-9975873-B2 | Isoindoline derivatives | UCB BIOPHARMA SPRL (BE) | 2018-05-22 | — | — | US | disclosed |
| US-20170313677-A1 | Isoindoline Derivatives | UCB BIOPHARMA SPRL (BE) | 2017-11-02 | — | — | US | disclosed |
| US-20170313677-A1 | Isoindoline Derivatives | UCB BIOPHARMA SPRL (BE) | 2017-11-02 | — | — | US | disclosed |
| US-20080097111-A1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2008-04-24 | — | — | US | disclosed |
| US-7307175-B2 | Process for the preparation of 7-substituted 3-alkyl-3H-isobenzofuran-1-one derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2007-12-11 | — | — | US | disclosed |
| US-20040158080-A1 | Process for the preparation of 7-substituted 3-alkyl-3h-isobenzofuran-1-one derivatives | SYNGENTA CROP PROTECTION, INC. | 2004-08-12 | — | — | US | disclosed |
| EP-1390339-A2 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | Syngenta Participations AG (CH) | 2004-02-25 | — | — | EP | disclosed |
| US-6657085-B2 | By reacting nitro compounds with hydrazine at elevated temperature in the presence of an aqueous base; intermediates in the preparation of herbicides of the isobenzofuranone type | SYNGENTA CROP PROTECTION, INC. | 2003-12-02 | — | — | US | disclosed |
| US-20030114690-A1 | Process for the preparation of aniline compounds | SYNGENTA CROP PROTECTION, INC. | 2003-06-19 | — | — | US | disclosed |
| EP-1286949-A2 | PROCESS FOR THE PREPARATION OF ANILINE COMPOUNDS | Syngenta Participations AG (CH) | 2003-03-05 | — | — | EP | disclosed |
| WO-2002094760-A2 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2002-11-28 | — | — | WO | disclosed |
| WO-2001087806-A2 | PROCESS FOR THE PREPARATION OF ANILINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2001-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080097111-A1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | C1S, C1R, C3AR1 | ADORA2A 2191/4885PTPRC 2892/4885MAOA 574/4885 |
| US-20170313677-A1 | Isoindoline Derivatives | OPRD1, ADRA1D, DRD2 | ADORA2A 60/4885PTPRC 3617/4885MAOA 1055/4885 |
| US-20030114690-A1 | Process for the preparation of aniline compounds | CYP1B1, CYP1A1, CYP1A2 | ADORA2A 1929/4885PTPRC 3833/4885MAOA 162/4885 |
| US-20040158080-A1 | Process for the preparation of 7-substituted 3-alkyl-3h-isobenzofuran-1-one derivatives | CBR1, AFF1, ALK | ADORA2A 4792/4885PTPRC 3353/4885MAOA 1976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.