SCHEMBL1870478

SCHEMBL1870478

O=C(O)CN1CCC(C(=O)O)CC1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.48
L3MBTL1 Q9Y468 2/20 0.42
KDM4E B2RXH2 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.41
LMNA P02545 2/20 0.40
TSHR P16473 2/20 0.40
PLG P00747 1/20 0.40
PLAT P00750 1/20 0.40
CYP2C19 P33261 1/20 0.40
ITGB3 P05106 1/20 0.40
ITGA2B P08514 1/20 0.40
GABRP O00591 1/20 0.39
GABRD O14764 1/20 0.39
GABRA1 P14867 1/20 0.39
GABRB1 P18505 1/20 0.39
GABRG2 P18507 1/20 0.39
GABRB3 P28472 1/20 0.39
GABRA5 P31644 1/20 0.39
GABRA3 P34903 1/20 0.39
GABRA2 P47869 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18975305 0.86 MEN1 (0.38) HSD17B10L3MBTL1KDM4ESMN1; SMN2
SCHEMBL16228133 0.84 HSD17B10 (0.50) HSD17B10SMN1; SMN2TSHRITGB3ITGA2B
SCHEMBL21675522 0.83 SMN1; SMN2 (0.42) HSD17B10L3MBTL1KDM4ESMN1; SMN2LMNA
SCHEMBL14621507 0.83 HSD17B10 (0.45) HSD17B10KDM4ESMN1; SMN2ITGB3ITGA2B
SCHEMBL9912438 0.83 KDM4E (0.50) L3MBTL1KDM4ESMN1; SMN2LMNATSHR
SCHEMBL7765808 0.83 SMN1; SMN2 (0.62) HSD17B10KDM4ESMN1; SMN2
SCHEMBL19514340 0.81 LTA4H (0.47) L3MBTL1KDM4ESMN1; SMN2LMNATSHR
Water SCHEMBL28581624 0.81 SMN1; SMN2 (0.60) HSD17B10KDM4ESMN1; SMN2
SCHEMBL23291292 0.79 HSD17B10 (0.56) HSD17B10KDM4ETSHRITGB3ITGA2B
SCHEMBL9839122 0.79 L3MBTL1 (0.44) L3MBTL1KDM4ESMN1; SMN2LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250296915-A1 NOVEL AMINO ACID DERIVATIVES PEPTIDREAM INC (JP) 2025-09-25 US claimed
US-20250296915-A1 NOVEL AMINO ACID DERIVATIVES PEPTIDREAM INC (JP) 2025-09-25 US disclosed
CN-119977991-A Medicine for treating severe malaria and synthesis method thereof 中国中医科学院中药研究所 2025-05-13 CN disclosed
CN-116077553-B Dressing containing walnut shell extract for promoting wound healing and preparation method thereof 西安交通大学 2024-05-24 CN disclosed
CN-116077553-A Application of walnut shell extract in promoting wound healing, wound dressing based on walnut shell extract and preparation method of wound dressing 西安交通大学 2023-05-09 CN disclosed
US-10689430-B2 Insulin receptor partial agonists MERCK SHARP & DOHME CORP. (US) 2020-06-23 US disclosed
US-20190177393-A1 INSULIN RECEPTOR PARTIAL AGONISTS MERCK SHARP & DOHME CORP. (US) 2019-06-13 US disclosed
EP-1870396-B1 BENZYLOXYPROPYLAMINE DERIVATIVE NIPPON ZOKI PHARMACEUTICAL CO (JP) 2012-10-31 EP disclosed
US-7939552-B2 Tachykinin receptor anatgonist; good transfer into blood; long half-life; stability; bradycardial agents; antiinflammatory agents ; antallergens; analgesics; antiemetics; irritable bowel disorders; skin disorders; antidepressants; antiischemic agents ; anxiolytic agents; autoimmune diseases; muscle relax NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) 2011-05-10 US disclosed
US-20080262230-A1 Benzyloxypropylamine Derivative NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) 2008-10-23 US disclosed
EP-1870396-A1 BENZYLOXYPROPYLAMINE DERIVATIVE Nippon Zoki Pharmaceutical Co. Ltd. (JP) 2007-12-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250296915-A1 NOVEL AMINO ACID DERIVATIVES DNPEP, BCAT1, ANPEP HSD17B10 4316/4885L3MBTL1 1947/4885KDM4E 4163/4885
US-20190177393-A1 INSULIN RECEPTOR PARTIAL AGONISTS INSR, GPR119, IRS1 HSD17B10 2172/4885L3MBTL1 3741/4885KDM4E 4815/4885
US-10689430-B2 Insulin receptor partial agonists INSR, GPR119, IRS1 HSD17B10 2172/4885L3MBTL1 3741/4885KDM4E 4815/4885
US-20080262230-A1 Benzyloxypropylamine Derivative BDKRB2, BDKRB1, PNMT HSD17B10 3799/4885L3MBTL1 1221/4885KDM4E 2622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.