SCHEMBL18758174

SCHEMBL18758174

COc1ccc(-c2ccc(/C(=N/N)NN)cc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 4/20 0.51
CA2 P00918 4/20 0.51
ESR2 Q92731 1/20 0.46
ALDH1A1 P00352 3/20 0.43
NPC1 O15118 3/20 0.43
RAB9A P51151 3/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
KDM4E B2RXH2 1/20 0.43
POLB P06746 1/20 0.43
GAA P10253 1/20 0.43
PRSS1 P07477 1/20 0.43
PRSS2 P07478 1/20 0.43
PRSS3 P35030 1/20 0.43
PARP1 P09874 1/20 0.43
PARP10 Q53GL7 1/20 0.43
PARP2 Q9UGN5 1/20 0.43
PARP4 Q9UKK3 1/20 0.43
MAP4K4 O95819 1/20 0.42
MAPT P10636 1/20 0.42
HTT P42858 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7318116 0.75 CA1 (0.89) CA1CA2ALDH1A1NPC1RAB9A
SCHEMBL21339965 0.75 MAPT (0.61) CA1CA2ALDH1A1NPC1RAB9A
SCHEMBL10624821 0.73 RAB9A (0.59) ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL10624825 0.73 RAB9A (0.59) ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL20363975 0.72 MAOA (0.46) CA2ALDH1A1NPC1RAB9AKDM4E
SCHEMBL20777964 0.71 MASP2 (0.39) CA1CA2ALDH1A1NPC1RAB9A
SCHEMBL19533157 0.71 CA1 (0.48) CA1CA2ALDH1A1NPC1RAB9A
SCHEMBL21339902 0.70 OGG1 (0.52) CA1CA2ALDH1A1NPC1RAB9A
SCHEMBL10033601 0.70 CA1 (0.52) CA1CA2ALDH1A1SMN1; SMN2PRSS1
SCHEMBL15054199 0.70 CA1 (0.52) CA1CA2ALDH1A1SMN1; SMN2PRSS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017064490-A1 CROSS-LINKABLE CHARGE TRANSPORT MATERIALS LOMOX LIMITED (GB) 2017-04-20 WO disclosed