Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ACP3 | P15309 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | GALR1 | P47211 | 1/20 | 0.38 |
| ▸ | P4HB | P07237 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2096273 | 0.79 | NFKB1 (0.35) | NFKB1GAALMNAALDH1A1POLB | |
| SCHEMBL8630737 | 0.79 | NFKB1 (0.35) | NFKB1GAALMNAALDH1A1POLB | |
| SCHEMBL14932033 | 0.79 | HSD11B1 (0.41) | NFKB1GAALMNAALDH1A1POLB | |
| SCHEMBL63469 | 0.78 | ALDH1A1 (0.52) | NFKB1GAALMNAALDH1A1POLB | |
| SCHEMBL29441997 | 0.78 | ALDH1A1 (0.52) | NFKB1GAALMNAALDH1A1POLB | |
| SCHEMBL2051652 | 0.77 | MPL (0.43) | GAALMNAALDH1A1POLBTDP1 | |
| Hydrogen Sulfide SCHEMBL28274662 | 0.76 | ALDH1A1 (0.50) | NFKB1GAALMNAALDH1A1POLB | |
| SCHEMBL10368048 | 0.75 | RXRA (0.41) | GAALMNAIDO1 | |
| SCHEMBL2799903 | 0.75 | P2RX7 (0.53) | MEN1KMT2A | |
| SCHEMBL2185812 | 0.75 | NFKB1 (0.33) | NFKB1GAALMNAACP3TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1172 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11987588-B2 | Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure and disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2024-05-21 | — | — | US | claimed |
| CN-116478400-A | Polyimide and diamine monomer containing tetrabiphenyl derivative structure and preparation method thereof | 中山大学 | 2023-07-25 | — | — | CN | claimed |
| EP-3720858-B1 | MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2023-06-07 | — | — | EP | claimed |
| CN-115960355-A | Method for preparing sulfur-containing polymer based on isomerization-driven irreversible ring-opening polymerization | 中国科学院上海有机化学研究所 | 2023-04-14 | — | — | CN | claimed |
| US-20220396579-A1 | MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2022-12-15 | — | — | US | claimed |
| EP-3867333-B1 | DISUBSTITUTED DIARYLOXYBENZOHETERODIAZOLE COMPOUNDS | ENI SPA (IT) | 2022-09-14 | — | — | EP | claimed |
| EP-4028400-A1 | SUBSTITUTED IMIDAZOQUINOXALINE COMPOUNDS AND USES THEREOF | Impact Therapeutics (Shanghai), Inc (CN) | 2022-07-20 | — | — | EP | claimed |
| CN-114583278-A | Low-temperature electrolyte of lithium ion battery and lithium ion battery | 傲普(上海)新能源有限公司 | 2022-06-03 | — | — | CN | claimed |
| CN-113166138-A | Disubstituted diaryloxybenzoheterodiazole compounds | 艾尼股份公司 | 2021-07-23 | — | — | CN | claimed |
| CN-112574177-A | Pyrimidine derivatives and application thereof in preparing antitumor drugs | 陕西师范大学 | 2021-03-30 | — | — | CN | claimed |
| EP-0421747-A2 | (Fluorinated phenoxy) (3-perfluoro-alkylphenoxy)-cyclic phosphazenes and process for preparing the same | THE DOW CHEMICAL COMPANY (US) | 1991-04-10 | — | — | EP | claimed |
| EP-0190037-B1 | PROCESS FOR PREPARING AN AZIRIDINE DERIVATIVE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-11-30 | — | — | EP | claimed |
| US-4705794-A | Ischaemia or hypoxia controlling compositions containing pyridinecarboxylic acid esters | BAYER AKTIENGESELLSCHAFT (DE) | 1987-11-10 | — | — | US | claimed |
| US-4659720-A | POULTRY ANTIPROTOZOA AGENT | MERCK & CO., INC. (US) | 1987-04-21 | — | — | US | claimed |
| EP-0113570-B1 | 5-(AMINO OR SUBSTITUTED AMINO) IMIDAZOLES | MERCK & CO. INC. (US) | 1987-02-25 | — | — | EP | claimed |
| US-4622330-A | Antiprotozoal 3-amino or substituted amino pyrazoles | MERCK & CO., INC. (US) | 1986-11-11 | — | — | US | claimed |
| EP-0113570-A1 | 5-(Amino or substituted amino) imidazoles | MERCK & CO. INC. (US) | 1984-07-18 | — | — | EP | claimed |
| EP-0103445-A2 | Process for production of prostaglandins E or F, and novel 7-(thiocarbo-acyloxy) prostaglandins E or F | TEIJIN LIMITED (JP) | 1984-03-21 | — | — | EP | claimed |
| EP-0040021-A1 | Amides and sulfonamides of prostaglandine-type compounds and compositions containing them | THE UPJOHN COMPANY (US) | 1981-11-18 | — | — | EP | claimed |
| US-3931155-A | ANTICOAGULANT | RICHARDSON-MERRELL INC. (US) | 1976-01-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11987588-B2 | Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure and disorders related thereto | ADRB3, ADRB1, ADRB2 | NFKB1 1224/4885GAA 1959/4885LMNA 1377/4885 |
| US-20220396579-A1 | MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO | ADRB3, ADRB1, ADRB2 | NFKB1 1318/4885GAA 1863/4885LMNA 1281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.