Potassium Ion

Potassium Ion

SCHEMBL18784182

CCCS(=O)(=O)c1cccnc1C(=O)[O-].[K+]

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA

The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.42
HTT P42858 1/20 0.42
COMT P21964 1/20 0.38
ADRA2C P18825 2/20 0.37
ADRA1D P25100 2/20 0.37
ADRA1A P35348 2/20 0.37
ADRA1B P35368 2/20 0.37
UBE2N P61088 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
KDM4E B2RXH2 4/20 0.35
MAPT P10636 3/20 0.35
GAA P10253 2/20 0.35
NPSR1 Q6W5P4 2/20 0.35
APOBEC3G Q9HC16 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
ALDH1A1 P00352 2/20 0.35
HPGD P15428 1/20 0.35
HSD17B10 Q99714 1/20 0.35
LMNA P02545 1/20 0.34
L3MBTL1 Q9Y468 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18784122 0.97 TSHR (0.42) TSHRHTTCOMTADRA2CADRA1D
Lithium Ion SCHEMBL18784188 0.97 TSHR (0.42) TSHRHTTCOMTADRA2CADRA1D
Potassium Ion SCHEMBL18784201 0.92 TSHR (0.40) TSHRHTTCOMTKDM4EMAPT
Potassium Ion SCHEMBL18784160 0.89 COMT (0.48) TSHRHTTCOMTKDM4EMAPT
SCHEMBL18784204 0.89 TSHR (0.40) TSHRHTTCOMTKDM4EMAPT
Lithium Ion SCHEMBL18784179 0.89 TSHR (0.40) TSHRHTTCOMTKDM4EMAPT
Lithium Ion SCHEMBL18784153 0.86 COMT (0.48) TSHRHTTCOMTKDM4EMAPT
SCHEMBL18784138 0.86 COMT (0.48) TSHRHTTCOMTKDM4EMAPT
SCHEMBL18784208 0.85 TSHR (0.47) TSHRHTTCOMTADRA2CADRA1D
SCHEMBL18940883 0.84 KDM4E (0.44) TSHRHTTCOMTADRA2CADRA1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3162795-B1 METHOD FOR MANUFACTURING 3-(ALKYL SULFONYL)PYRIDINE-2-CARBOXYLIC ACID SUMITOMO CHEMICAL CO (JP) 2019-07-31 EP disclosed
US-9815786-B2 Method for manufacturing 3-(alkylsulfonyl)pyridine-2-carboxylic acid SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2017-11-14 US disclosed
US-20170129859-A1 METHOD FOR MANUFACTURING 3-(ALKYLSULFONYL)PYRIDINE-2-CARBOXYLIC ACID SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2017-05-11 US disclosed
EP-3162795-A1 METHOD FOR MANUFACTURING 3-(ALKYL SULFONYL)PYRIDINE-2-CARBOXYLIC ACID Sumitomo Chemical Company, Limited (JP) 2017-05-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170129859-A1 METHOD FOR MANUFACTURING 3-(ALKYLSULFONYL)PYRIDINE-2-CARBOXYLIC ACID STS, SRM, CERS2 TSHR 957/4885HTT 3755/4885COMT 3319/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.