Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18797741 | 0.84 | NOTUM (0.37) | ALDH1A1ALOX15NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1165021 | 0.83 | ALDH1A1 (0.44) | ALDH1A1ALOX15P2RX7GAACES2 | |
| SCHEMBL8675762 | 0.79 | ALDH1A1 (0.52) | ALDH1A1ALOX15P2RX7GAACES2 | |
| SCHEMBL18797706 | 0.78 | CA12 (0.40) | ALDH1A1NPC1RAB9AHPGDLMNA | |
| SCHEMBL28052874 | 0.78 | ALDH1A1 (0.38) | ALDH1A1ALOX15NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15809161 | 0.73 | CES2 (0.52) | ALDH1A1ALOX15LMNAGAAKMT2A | |
| SCHEMBL28172626 | 0.73 | KCNQ3 (0.37) | ALDH1A1ALOX15RAB9ACES2DAO | |
| SCHEMBL14660959 | 0.72 | DPP4 (0.36) | ALOX15NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL16122077 | 0.72 | ALDH1A1 (0.41) | ALDH1A1ALOX15CES2CES1 | |
| SCHEMBL27630874 | 0.71 | ALDH1A1 (0.46) | ALDH1A1ALOX15GAAKMT2ACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3368535-B1 | HETEROARYL SUBSTITUTED BENZOIC ACIDS AS RORGAMMAT INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME (US) | 2020-12-02 | — | — | EP | disclosed |
| EP-3368535-B1 | HETEROARYL SUBSTITUTED BENZOIC ACIDS AS RORGAMMAT INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME (US) | 2020-12-02 | — | — | EP | disclosed |
| US-10584121-B2 | Heteroaryl substituted benzoic acids as RORgammaT inhibitors and uses thereof | MERCK SHARP & DOHME CORP. (US) | 2020-03-10 | — | — | US | disclosed |
| US-20190194186-A1 | HETEROARYL SUBSTITUTED BENZOIC ACIDS AS RORgammaT INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME LLC | 2019-06-27 | — | — | US | disclosed |
| EP-3368535-A1 | HETEROARYL SUBSTITUTED BENZOIC ACIDS AS RORGAMMAT INHIBITORS AND USES THEREOF | Merck Sharp & Dohme Corp. (US) | 2018-09-05 | — | — | EP | disclosed |
| WO-2017075185-A1 | HETEROARYL SUBSTITUTED BENZOIC ACIDS AS RORGAMMAT INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME CORP. (US) | 2017-05-04 | — | — | WO | disclosed |
| WO-2017075185-A1 | HETEROARYL SUBSTITUTED BENZOIC ACIDS AS RORGAMMAT INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME CORP. (US) | 2017-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190194186-A1 | HETEROARYL SUBSTITUTED BENZOIC ACIDS AS RORgammaT INHIBITORS AND USES THEREOF | RORB, RORA, RORC | ALDH1A1 321/4885ALOX15 1864/4885NPC1 600/4885 |
| US-10584121-B2 | Heteroaryl substituted benzoic acids as RORgammaT inhibitors and uses thereof | RORB, RORA, RORC | ALDH1A1 321/4885ALOX15 1864/4885NPC1 600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.