Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | PDE11A | Q9HCR9 | 4/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800885 | 0.90 | BTK (0.48) | BTKPDE11AMAPK10ALDH1A1 | |
| SCHEMBL18800884 | 0.89 | BTK (0.42) | BTKSYKNPC1RAB9AHTT | |
| SCHEMBL18800772 | 0.89 | ADORA1 (0.43) | BTKPDE11ASYKMEN1KMT2A | |
| SCHEMBL18800468 | 0.86 | BTK (0.49) | BTKPDE11ALMNAHSD17B10ALDH1A1 | |
| SCHEMBL18800792 | 0.84 | BTK (0.47) | BTKLMNAMAPK10 | |
| SCHEMBL18800891 | 0.84 | BTK (0.62) | BTKSYKMEN1KMT2ATSHR | |
| SCHEMBL18800886 | 0.83 | BTK (0.42) | BTKNPC1LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL18800784 | 0.83 | BTK (0.46) | BTK | |
| SCHEMBL18800466 | 0.76 | DHODH (0.42) | BTKMEN1KMT2ALMNATSHR | |
| SCHEMBL18800760 | 0.74 | BTK (0.61) | BTKLMNAHSD17B10TP53MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |