Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800884 | 0.89 | BTK (0.42) | BTKHSD17B10NPC1SMN1; SMN2LMNA | |
| SCHEMBL18800559 | 0.84 | BTK (0.58) | BTKCSF1RNPC1SMN1; SMN2 | |
| SCHEMBL18800558 | 0.83 | BTK (0.43) | BTKHSD17B10NPC1SMN1; SMN2LMNA | |
| SCHEMBL18800468 | 0.81 | BTK (0.49) | BTKHSD17B10LMNACYP1A2CYP3A4 | |
| SCHEMBL18800885 | 0.79 | BTK (0.48) | BTK | |
| SCHEMBL18800772 | 0.77 | ADORA1 (0.43) | BTKHSD17B10LMNAALOX15 | |
| SCHEMBL18800792 | 0.76 | BTK (0.47) | BTKLMNA | |
| SCHEMBL18800891 | 0.75 | BTK (0.62) | BTK | |
| SCHEMBL18800760 | 0.70 | BTK (0.61) | BTKHSD17B10LMNACYP1A2CYP3A4 | |
| SCHEMBL18800563 | 0.67 | BTK (0.58) | BTKHSD17B10SMN1; SMN2LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |