Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18834221 | 0.80 | P2RX3 (0.40) | TP53PDE5APDE4APDE4BPDE4C | |
| SCHEMBL19374868 | 0.78 | P2RX3 (0.36) | P2RX3TSHRLMNAADORA3 | |
| SCHEMBL19375602 | 0.75 | ADORA3 (0.43) | TP53PPARGTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL18834562 | 0.74 | P2RX7 (0.40) | TP53PDE5APDE4APDE4BPDE4C | |
| SCHEMBL8007895 | 0.73 | PDE5A (0.39) | PDE5ATSHRALDH1A1RAB9AMEN1 | |
| SCHEMBL31466679 | 0.73 | TRPC5 (0.51) | ALDH1A1RAB9AMAPTKMT2AADORA3 | |
| SCHEMBL16028419 | 0.73 | TRPC5 (0.51) | ALDH1A1RAB9AMAPTKMT2AADORA3 | |
| SCHEMBL18834150 | 0.72 | OPRK1 (0.36) | TP53MDM2PPARGTSHRMEN1 | |
| SCHEMBL20432560 | 0.72 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL19375051 | 0.71 | MDM2 (0.38) | TP53MDM2P2RX3LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |