Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 11/20 | 0.39 |
| ▸ | TRPC5 | Q9UL62 | 3/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18834975 | 0.89 | KDM4E (0.39) | TRPC5ADORA3TSHRPDE5APDE4A | |
| SCHEMBL20432069 | 0.82 | TRPC5 (0.36) | TRPC5ADORA3TSHRLMNAHPGD | |
| SCHEMBL21499716 | 0.81 | PDE4A (0.38) | ADORA3TSHRPDE5APDE4APDE4B | |
| SCHEMBL19375039 | 0.81 | RAB9A (0.36) | ADORA3TSHRLMNASMN1; SMN2 | |
| SCHEMBL22105398 | 0.81 | MEN1 (0.50) | ADORA3PDE5APDE4APDE4BPDE4C | |
| SCHEMBL18834366 | 0.80 | TRPC5 (0.38) | TRPC5 | |
| SCHEMBL21316348 | 0.80 | ALDH1A1 (0.40) | TRPC5ADORA3TSHRPDE5APDE4A | |
| SCHEMBL21316344 | 0.80 | P2RX3 (0.40) | ADORA3PDE5APDE4APDE4BPDE4C | |
| SCHEMBL19375150 | 0.80 | USP1 (0.41) | USP1TRPC5 | |
| SCHEMBL18834435 | 0.79 | MAPT (0.39) | TRPC5ADORA3TSHRPDE5AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |