Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18834975 | 0.93 | KDM4E (0.39) | TRPC5LMNATSHRCNR1CNR2 | |
| SCHEMBL19375039 | 0.90 | RAB9A (0.36) | CYP2D6HRH1MAPTLMNAP2RX3 | |
| SCHEMBL18834436 | 0.88 | PPARG (0.36) | CYP2D6HRH1MAPTLMNAP2RX3 | |
| SCHEMBL18833918 | 0.86 | P2RX3 (0.35) | TRPC5CYP2D6HRH1P2RX3TSHR | |
| SCHEMBL19505584 | 0.84 | P2RX7 (0.39) | P2RX3KMT2ATSHRP2RX7ALDH1A1 | |
| SCHEMBL18834470 | 0.83 | TRPC5 (0.35) | TRPC5P2RX3TSHRCNR1CNR2 | |
| SCHEMBL20432432 | 0.82 | PDE5A (0.37) | TRPC5P2RX3TSHRALDH1A1ADORA3 | |
| SCHEMBL21499680 | 0.82 | P2RX3 (0.39) | TRPC5CYP2D6HRH1MAPTP2RX3 | |
| SCHEMBL18835033 | 0.82 | USP1 (0.39) | TRPC5LMNATSHRHPGDADORA3 | |
| SCHEMBL18835230 | 0.81 | ALDH1A1 (0.41) | CYP2D6HRH1MAPTLMNAP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B3 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2018-08-01 | — | — | EP | disclosed |