Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Levomefolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD1 | P11586 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | DHFR | P00374 | 1/20 | 0.70 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.60 |
| ▸ | FPGS | Q05932 | 2/20 | 0.59 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.55 |
| ▸ | TYMS | P04818 | 1/20 | 0.52 |
| ▸ | ATIC | P31939 | 3/20 | 0.50 |
| ▸ | GART | P22102 | 6/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levomefolic Acid SCHEMBL29506219 | 1.00 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL692440 | 1.00 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL1883636 | 1.00 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL30733832 | 1.00 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL9487492 | 0.99 | MTHFD1 (0.74) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL9877418 | 0.99 | MTHFD1 (0.74) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL15124392 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL9485861 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL19252687 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL9486318 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024175614-A1 | STABLE LIQUID FORMULATIONS COMPRISING (6S)-5-METHYLTETRAHYDROFOLIC ACID OR SALTS THEREOF | MERCK PATENT GMBH (DE) | 2024-08-29 | — | — | WO | claimed |
| CN-120131660-A | Composition and application thereof | 北京斯利安药业有限公司 | 2025-06-13 | — | — | CN | disclosed |
| CN-112368269-B | Crystalline salts comprising 5-methyl- (6S) -tetrahydrofolic acid and 4- (2-hydroxyethyl) -morpholine | 默克专利股份有限公司 | 2025-04-11 | — | — | CN | disclosed |
| US-12221445-B2 | Crystalline salts of 5-methyl-(6S)-tetrahydrofolic acid and amino ethyl esters | MERCK PATENT GMBH (DE) | 2025-02-11 | — | — | US | disclosed |
| CN-118702699-A | Preparation method of impurity C and impurity D in L-5-methyltetrahydrofolate calcium | 北京斯利安药业有限公司 | 2024-09-27 | — | — | CN | disclosed |
| WO-2024175614-A1 | STABLE LIQUID FORMULATIONS COMPRISING (6S)-5-METHYLTETRAHYDROFOLIC ACID OR SALTS THEREOF | MERCK PATENT GMBH (DE) | 2024-08-29 | — | — | WO | disclosed |
| US-11992491-B2 | Crystalline salts of 5-methyl-(6S)-tetrahydrofolic acid and L-valine ethyl ester | MERCK PATENT GMBH (DE) | 2024-05-28 | — | — | US | disclosed |
| US-11925644-B2 | Crystalline salts of 5-methyl-(6S)-tetrahydrofolic acid and l-leucine ethyl ester | MERCK PATENT GMBH (DE) | 2024-03-12 | — | — | US | disclosed |
| CN-117448245-A | Recombinant genetic engineering bacterium and preparation method of (6S) -5-methyltetrahydrofolate | 上海锐康生物技术研发有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-117322470-A | 6S-5-methyltetrahydrofolate calcium fortified sterilized milk and preparation method thereof | 江苏海洋大学 | 2024-01-02 | — | — | CN | disclosed |
| EP-3818048-B1 | CRYSTALLINE SALT COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLIC ACID AND 4-(2-HYDROXYETHYL)-MORPHOLINE | MERCK PATENT GMBH (DE) | 2023-09-20 | — | — | EP | disclosed |
| EP-3817812-B1 | CRYSTALLINE SALT OF 5-METHYL-(6S)-TETRAHYDROFOLIC ACID AND L-ISOLEUCINE ETHYL ESTER | MERCK PATENT GMBH (DE) | 2023-09-20 | — | — | EP | disclosed |
| EP-3817814-B1 | CRYSTALLINE SALTS OF 5-METHYL-(6S)-TETRAHYDROFOLIC ACID AND L-VALINE ETHYL ESTER | MERCK PATENT GMBH (DE) | 2023-09-20 | — | — | EP | disclosed |
| EP-3817813-B1 | CRYSTALLINE SALTS OF 5-METHYL-(6S)-TETRAHYDROFOLIC ACID AND L-LEUCINE ETHYL ESTER | MERCK PATENT GMBH (DE) | 2023-09-20 | — | — | EP | disclosed |
| CN-116718714-A | Method for measuring 6S-5-methyltetrahydrofolate calcium in collagen membrane material by high performance liquid chromatography | 江苏海洋大学 | 2023-09-08 | — | — | CN | disclosed |
| US-11633400-B2 | Crystalline salt comprising 5-methyl-(6S)-tetrahydrofolic acid and 4-(2-hydroxyethyl)-morpholine | MERCK PATENT GMBH (DE) | 2023-04-25 | — | — | US | disclosed |
| CN-115605188-A | Compositions comprising methylfolic acid | 阿尔法西格玛有限公司（IT） | 2023-01-13 | — | — | CN | disclosed |