Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR known ✓ | P00374 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11457374 | 0.88 | LMNA (0.49) | LMNAMAPTTSHRL3MBTL1TDP1 | |
| SCHEMBL29381732 | 0.84 | RAB9A (0.54) | LMNAMAPTTSHRL3MBTL1TDP1 | |
| SCHEMBL117098 | 0.84 | RAB9A (0.54) | LMNAMAPTTSHRL3MBTL1TDP1 | |
| Potassium Ion SCHEMBL1890648 | 0.82 | MAPT (0.67) | LMNAMAPTTSHRL3MBTL1TDP1 | |
| 2,4,5-Trichlorophenoxyacetic Acid SCHEMBL1885275 | 0.80 | LMNA (0.61) | LMNAMAPTTSHRL3MBTL1TDP1 | |
| SCHEMBL5311708 | 0.79 | MAPT (0.67) | LMNAMAPTTSHRL3MBTL1TDP1 | |
| SCHEMBL5339875 | 0.77 | LMNA (0.49) | LMNATSHRL3MBTL1TDP1RAB9A | |
| SCHEMBL6288400 | 0.77 | LMNA (0.51) | LMNATSHRL3MBTL1TDP1RAB9A | |
| 2,4,5-Trichlorophenoxyacetic Acid SCHEMBL4587919 | 0.77 | LMNA (0.61) | LMNAMAPTTSHRL3MBTL1TDP1 | |
| 2,4,5-Trichlorophenoxyacetic Acid SCHEMBL162303 | 0.77 | LMNA (0.61) | LMNAMAPTTSHRL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012363-B2 | Granular controlled release agrochemical compositions and process for the preparation thereof | EVERRIS INTERNATIONAL B.V. (NL) | 2015-04-21 | — | — | US | disclosed |
| EP-1928231-B1 | GRANULAR CONTROLLED RELEASE AGROCHEMICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF | EVERRIS INTERNAT B V (NL) | 2014-03-12 | — | — | EP | disclosed |
| US-20130310255-A1 | GRANULAR CONTROLLED RELEASE AGROCHEMICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF | OMS INVESTMENTS, INC. | 2013-11-21 | — | — | US | disclosed |
| US-8497229-B2 | Granular controlled release agrochemical compositions and process for the preparation thereof | EVERRIS INTERNATIONAL B.V. (NL) | 2013-07-30 | — | — | US | disclosed |
| EP-2545775-A2 | Granular controlled release agrochemical compositions and process for the preparation thereof | Everris International B.V. (NL) | 2013-01-16 | — | — | EP | disclosed |
| EP-1370135-B1 | CONTROLLED RELEASE PRODUCTS AND PROCESSES FOR THE PREPARATION THEREOF | EVERRIS INTERNAT B V (NL) | 2012-05-30 | — | — | EP | disclosed |
| US-20110111956-A1 | Granular Controlled Release Agrochemical Compositions and Process for the Preparation Thereof | OMS INVESTMENTS, INC. (US) | 2011-05-12 | — | — | US | disclosed |
| EP-1928231-A2 | GRANULAR CONTROLLED RELEASE AGROCHEMICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF | OMS Investments, Inc. (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007041234-A2 | GRANULAR CONTROLLED RELEASE AGROCHEMICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF | OMS INVESTMENTS, INC. (US) | 2007-04-12 | — | — | WO | disclosed |
| US-20070072775-A1 | Granular controlled release agrochemical compositions and process for the preparation thereof | OMS INVESTMENTS, INC. (US) | 2007-03-29 | — | — | US | disclosed |
| US-6987082-B2 | Controlled release products and processes for the preparation thereof | OMS INVESTMENTS, INC. (US) | 2006-01-17 | — | — | US | disclosed |
| US-20040069033-A1 | Controlled release products and processes for the preparation thereof | OMS INVESTMENTS, INC. | 2004-04-15 | — | — | US | disclosed |
| EP-1370135-A1 | CONTROLLED RELEASE PRODUCTS AND PROCESSES FOR THE PREPARATION THEREOF | OMS Investments, Inc. (US) | 2003-12-17 | — | — | EP | disclosed |
| US-6656882-B2 | Coated products in particulate form which are structured to provide release profiles wherein initial release of active ingredients such as fertilizer nutrients is suppressed or for predetermined period and longevity for release within 60 days | OMS INVESTMENTS, INC. | 2003-12-02 | — | — | US | disclosed |
| US-20020168318-A1 | Controlled release products and processes for the preparation thereof | OMS INVESTMENTS, INC. | 2002-11-14 | — | — | US | disclosed |
| WO-2002068363-A2 | CONTROLLED RELEASE PRODUCTS AND PROCESSES FOR THE PREPARATION THEREOF | OMS INVESTMENTS, INC. (US) | 2002-09-06 | — | — | WO | disclosed |
| EP-0628527-B1 | Timed release of water-soluble plant nutrients | OMS INVESTMENTS INC (US) | 2001-04-11 | — | — | EP | disclosed |
| US-5652196-A | Timed release of water-soluble plant nutrients | OMS INVESTMENTS, INC. (US) | 1997-07-29 | — | — | US | disclosed |
| EP-0628527-A1 | Timed release of water-soluble plant nutrients | W.R. Grace & Co.-Conn. (US) | 1994-12-14 | — | — | EP | disclosed |
| US-4015970-A | FERTILIZER WITH POLYMERIC COATING | AIRWICK INDUSTRIES, INC. (US) | 1977-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040069033-A1 | Controlled release products and processes for the preparation thereof | GHITM, LBR, VMA21 | DHFR 2191/4885LMNA 623/4885MAPT 246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.