Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | PLA2G7 | Q13093 | 5/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | VHL | P40337 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.33 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18888856 | 0.80 | PLA2G7 (0.51) | PLA2G7ABL1PDGFRA | |
| SCHEMBL30105652 | 0.77 | LMNA (0.43) | PLA2G7ABL1PDGFRAMAPK14 | |
| SCHEMBL10319805 | 0.77 | LMNA (0.43) | PLA2G7ABL1PDGFRAMAPK14 | |
| SCHEMBL10304971 | 0.75 | TDO2 (0.56) | MKNK1MKNK2PLA2G7TDO2ABL1 | |
| SCHEMBL31469002 | 0.73 | MKNK1 (0.52) | MKNK1MKNK2TDO2ABL1TSHR | |
| SCHEMBL3421959 | 0.73 | MKNK1 (0.52) | MKNK1MKNK2TDO2ABL1TSHR | |
| SCHEMBL18889770 | 0.73 | ACHE (0.42) | PLA2G7ABL1PDGFRATSHRHTT | |
| SCHEMBL9963986 | 0.72 | NOS3 (0.46) | MKNK1MKNK2PLA2G7TDO2TSHR | |
| SCHEMBL2220714 | 0.71 | NR1H4 (0.41) | PLA2G7ABL1PDGFRA | |
| SCHEMBL21864313 | 0.70 | KDM4C (0.49) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928884-B1 | NOVEL BENZIMIDAZOLE DERIVATIVES AS EP4 ANTAGONISTS | Bayer Pharma AG (DE) | 2017-05-24 | — | — | EP | disclosed |