Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 1-Methylimidazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | QPCT | Q16769 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Methylimidazole SCHEMBL28157375 | 0.87 | ALDH1A1 (0.44) | NFKB1QPCTHSD17B10QPCTLALDH1A1 | |
| 1-Methylimidazole SCHEMBL17961221 | 0.85 | TSHR (0.53) | NFKB1QPCTHSD17B10QPCTLALDH1A1 | |
| SCHEMBL9309177 | 0.83 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2KDM4EMAPTTDP1 | |
| SCHEMBL4952812 | 0.81 | ALDH1A1 (0.57) | QPCTALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL2455924 | 0.80 | ALDH1A1 (0.53) | QPCTALDH1A1SMN1; SMN2KDM4EMAPT | |
| 1-Methylimidazole SCHEMBL4955404 | 0.78 | NFKB1 (0.71) | NFKB1QPCTHSD17B10QPCTLALDH1A1 | |
| 1-Methylimidazole SCHEMBL27681653 | 0.78 | NFKB1 (0.71) | NFKB1QPCTHSD17B10QPCTLALDH1A1 | |
| 1-Methylimidazole SCHEMBL693786 | 0.78 | NFKB1 (0.71) | NFKB1QPCTHSD17B10QPCTLALDH1A1 | |
| Fluoride SCHEMBL6570833 | 0.78 | GAA (0.59) | ALDH1A1SMN1; SMN2KDM4EMAPTTDP1 | |
| SCHEMBL135343 | 0.77 | LMNA (0.57) | HSD17B10ALDH1A1SMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 148 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119912350-A | Preparation method of isooctyl p-aminobenzoate | 江苏尚莱特医药化工材料有限公司 | 2025-05-02 | — | — | CN | claimed |
| CN-118994043-A | Preparation method of difluoro pyrazole acid | 湖南斯派克科技股份有限公司 | 2024-11-22 | — | — | CN | claimed |
| CN-118973288-A | Perovskite battery and preparation method thereof | 青海黄河上游水电开发有限责任公司西宁太阳能电力分公司 | 2024-11-15 | — | — | CN | claimed |
| CN-118546265-A | Cellulose aldehyde and preparation method and application thereof | 新疆农业大学 | 2024-08-27 | — | — | CN | claimed |
| CN-118390128-A | Copper/tin composite material with three-dimensional microstructure and preparation and application thereof | 上海大学 | 2024-07-26 | — | — | CN | claimed |
| CN-117923690-A | Apparatus and method for recovering acetonitrile mobile phase waste liquid generated by liquid chromatography | 中国石油化工股份有限公司 | 2024-04-26 | — | — | CN | claimed |
| CN-113416136-B | Application of acidic ionic liquid in catalyzing reaction of cinnamic acid and benzyl alcohol to prepare benzyl cinnamate and method for preparing benzyl cinnamate | 河南工业大学 | 2023-12-22 | — | — | CN | claimed |
| CN-113429345-B | Preparation method of acridone | 遂成药业股份有限公司 | 2023-12-01 | — | — | CN | claimed |
| CN-115710735-A | Electrotinning solution and preparation method and application thereof | 广东光华科技股份有限公司 | 2023-02-24 | — | — | CN | claimed |
| CN-114316823-A | Full-biological carbon dioxide-based biodegradable polyurethane pressure-sensitive adhesive tape and preparation method thereof | 中国科学院长春应用化学研究所 | 2022-04-12 | — | — | CN | claimed |
| EP-1789160-A1 | METHOD FOR SEPARATING HYDROGEN CHLORIDE AND PHOSGENE | BASF AKTIENGESELLSCHAFT (DE) | 2007-05-30 | — | — | EP | claimed |
| EP-1663921-B1 | METHOD FOR PRODUCING HALOALKANES FROM ALCOHOLS | BASF AG (DE) | 2007-05-02 | — | — | EP | claimed |
| US-20070055084-A1 | Method for producing haloalkanes from alcohols | BASF AKTIENGESELLSCHAFT (DE) | 2007-03-08 | — | — | US | claimed |
| US-20070034513-A1 | Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array | COMBIMATRIX CORPORATION | 2007-02-15 | — | — | US | claimed |
| WO-2006105037-A2 | ELECTROCHEMICAL DEBLOCKING SOLUTION FOR ELECTROCHEMICAL OLIGOMER SYNTHESIS ON AN ELECTRODE ARRAY | COMBIMATRIX CORPORATION (US) | 2006-10-05 | — | — | WO | claimed |
| EP-1663921-A2 | METHOD FOR PRODUCING HALOALKANES FROM ALCOHOLS | BASF AKTIENGESELLSCHAFT (DE) | 2006-06-07 | — | — | EP | claimed |
| WO-2006029788-A1 | METHOD FOR SEPARATING HYDROGEN CHLORIDE AND PHOSGENE | BASF AKTIENGESELLSCHAFT (DE) | 2006-03-23 | — | — | WO | claimed |
| WO-2006031814-A2 | ELECTROCHEMICAL DEBLOCKING USING A HYDRAZINE DERIVATIVE | COMBIMATRIX CORPORATION (US) | 2006-03-23 | — | — | WO | claimed |
| US-20060054511-A1 | Electrochemical deblocking using a hydrazine derivative | CUSTOMARRAY, INC. | 2006-03-16 | — | — | US | claimed |
| WO-2005026089-A2 | METHOD FOR PRODUCING HALOALKANES FROM ALCOHOLS | BASF AKTIENGESELLSCHAFT (DE) | 2005-03-24 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070055084-A1 | Method for producing haloalkanes from alcohols | ADH1C, HDHD5, ADH5 | NFKB1 2976/4885QPCT 510/4885HSD17B10 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.