Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR known ✓ | P04035 | 2/20 | 0.31 |
| ▸ | PPARG known ✓ | P37231 | 1/20 | 0.30 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.31 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.31 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | RARG | P13631 | 1/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29387295 | 0.92 | HSPA5 (0.44) | HMGCRNR5A2NR5A1HSPA5CYP2C19 | |
| SCHEMBL538260 | 0.92 | HSPA5 (0.44) | HMGCRNR5A2NR5A1HSPA5CYP2C19 | |
| Lithium Ion SCHEMBL30175563 | 0.91 | HSPA5 (0.43) | HMGCRNR5A2NR5A1HSPA5CYP2C19 | |
| SCHEMBL30175559 | 0.91 | HSPA5 (0.43) | HMGCRNR5A2NR5A1HSPA5CYP2C19 | |
| SCHEMBL538477 | 0.91 | HSPA5 (0.43) | HMGCRNR5A2NR5A1HSPA5CYP2C19 | |
| SCHEMBL29407271 | 0.91 | HSPA5 (0.43) | HMGCRNR5A2NR5A1HSPA5CYP2C19 | |
| SCHEMBL2334329 | 0.84 | INPPL1 (0.36) | HMGCRNR5A2NR5A1HSPA5CYP2C19 | |
| SCHEMBL29612109 | 0.84 | INPPL1 (0.36) | HMGCRNR5A2NR5A1HSPA5CYP2C19 | |
| SCHEMBL35073 | 0.83 | INPPL1 (0.35) | HMGCRNR5A2NR5A1HSPA5CYP2C19 | |
| SCHEMBL20299525 | 0.83 | INPPL1 (0.35) | HMGCRNR5A2NR5A1HSPA5CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9403956-B2 | Incipient wetness method to enhance productivity of supported Ziegler-Natta catalysts | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2016-08-02 | — | — | US | disclosed |
| EP-2953986-A1 | INCIPIENT WETNESS METHOD TO ENHANCE PRODUCTIVITY OF SUPPORTED ZIEGLER-NATTA CATALYSTS | ExxonMobil Chemical Patents Inc. (US) | 2015-12-16 | — | — | EP | disclosed |
| US-9000106-B2 | Copolymer production system and process | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2015-04-07 | — | — | US | disclosed |
| WO-2014123684-A1 | INCIPIENT WETNESS METHOD TO ENHANCE PRODUCTIVITY OF SUPPORTED ZIEGLER-NATTA CATALYSTS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2014-08-14 | — | — | WO | disclosed |
| US-20140221515-A1 | Incipient Wetness Method to Enhance Productivity of Supported Ziegler-Natta Catalysts | EXXONMOBIL CHEMICAL PATENTS INC. | 2014-08-07 | — | — | US | disclosed |
| US-20130296506-A1 | Copolymer Production System and Process | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2013-11-07 | — | — | US | disclosed |
| US-8076419-B2 | Method for making propylene impact copolymers with balanced impact strength and stiffness | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2011-12-13 | — | — | US | disclosed |
| US-20110105690-A1 | Method for Making Propylene Impact Copolymers with Balanced Impact Strength and Stiffness | EXXONMOBIL CHEMICAL PATENTS INC. | 2011-05-05 | — | — | US | disclosed |
| US-7851554-B2 | Propylene impact copolymers with balanced impact strength and stiffness | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2010-12-14 | — | — | US | disclosed |
| US-20100105848-A1 | Propylene Impact Copolymers With Balanced Impact Strength And Stiffness | EXXONMOBIL CHEMICAL PATENTS INC. | 2010-04-29 | — | — | US | disclosed |
| EP-1546245-A2 | POLYOLEFIN COMPOSITIONS EXHIBITING ENHANCED STAIN RESISTANCE | Sunoco, Inc. (R&M) (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20040171724-A1 | Polyolefin compositions exhibiting enhanced stain resistance | SEIP STEVEN D (US) | 2004-09-02 | — | — | US | disclosed |
| WO-2004031279-A2 | POLYOLEFIN COMPOSITIONS EXHIBITING ENHANCED STAIN RESISTANCE | SUNOCO, INC. (R & M) (US) | 2004-04-15 | — | — | WO | disclosed |