Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18940080 | 0.85 | TDP1 (0.39) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL18940025 | 0.81 | AKR1C3 (0.40) | AKR1C3AKR1C2LMNAPTGS2PTGS1 | |
| SCHEMBL18939899 | 0.80 | AKR1C3 (0.39) | AKR1C3AKR1C2LMNAEGLN1CCR2 | |
| SCHEMBL12278103 | 0.67 | AKR1C3 (0.47) | AKR1C3AKR1C2LMNAENPP2ALDH1A1 | |
| SCHEMBL12260002 | 0.67 | AKR1C3 (0.47) | AKR1C3AKR1C2LMNAENPP2ALDH1A1 | |
| SCHEMBL8035315 | 0.66 | HSD17B1 (0.54) | ENPP2PTGS2NQO2MTNR1AMTNR1B | |
| SCHEMBL7698123 | 0.66 | LMNA (0.42) | AKR1C3AKR1C2LMNACCR2PTGS2 | |
| SCHEMBL12508320 | 0.66 | AKR1C3 (0.58) | AKR1C3AKR1C2LMNAENPP2PTGS2 | |
| SCHEMBL18940102 | 0.65 | MMP13 (0.35) | LMNAEGLN1ALDH1A1KDM4E | |
| SCHEMBL15093582 | 0.65 | NSD2 (0.45) | AKR1C3AKR1C2LMNAENPP2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390396-B1 | ISOINDOLE COMPOUNDS | ASTRAZENECA AB (SE) | 2022-07-06 | — | — | EP | disclosed |
| US-20210380533-A1 | 2,3-DIHYDROISOINDOLE-1-CARBOXAMIDES USEFUL AS ROR-GAMMA MODULATORS | ASTRAZENECA AB (SE) | 2021-12-09 | — | — | US | disclosed |
| US-11034654-B2 | 2,3-dihydroisoindole-1-carboxamides useful as ROR-gamma modulators | ASTRAZENECA AB (SE) | 2021-06-15 | — | — | US | disclosed |
| US-10988445-B2 | Compounds | ASTRAZENECA AB (SE) | 2021-04-27 | — | — | US | disclosed |
| US-20200181084-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2020-06-11 | — | — | US | disclosed |
| EP-3638661-A1 | 2,3-DIHYDROISOINDOLE-1-CARBOXAMIDES USEFUL AS ROR-GAMMA MODULATORS | Astrazeneca AB (SE) | 2020-04-22 | — | — | EP | disclosed |
| US-20200115338-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2020-04-16 | — | — | US | disclosed |
| US-10526286-B2 | Compounds | ASTRAZENECA AB (SE) | 2020-01-07 | — | — | US | disclosed |
| US-20190084934-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2019-03-21 | — | — | US | disclosed |
| WO-2018229155-A1 | 2,3-DIHYDROISOINDOLE-1-CARBOXAMIDES USEFUL AS ROR-GAMMA MODULATORS | ASTRAZENECA AB (SE) | 2018-12-20 | — | — | WO | disclosed |
| EP-3390396-A1 | ISOINDOLE COMPOUNDS | Astrazeneca AB (SE) | 2018-10-24 | — | — | EP | disclosed |
| US-10011566-B2 | Compounds | ASTRAZENECA AB (SE) | 2018-07-03 | — | — | US | disclosed |
| WO-2017102784-A9 | ISOINDOLE COMPOUNDS | ASTRAZENECA AB (SE) | 2018-04-05 | — | — | WO | disclosed |
| WO-2017102784-A1 | ISOINDOLE COMPOUNDS | ASTRAZENECA AB (SE) | 2017-06-22 | — | — | WO | disclosed |
| US-20170166527-A1 | Novel Compounds | ASTRAZENECA AB (SE) | 2017-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10526286-B2 | Compounds | RORC, RORB, RORA | AKR1C3 818/4885AKR1C2 851/4885LMNA 4280/4885 |
| US-10988445-B2 | Compounds | RORC, RORB, RORA | AKR1C3 818/4885AKR1C2 851/4885LMNA 4280/4885 |
| US-10011566-B2 | Compounds | RORC, RORB, RORA | AKR1C3 818/4885AKR1C2 851/4885LMNA 4280/4885 |
| US-20200115338-A1 | NOVEL COMPOUNDS | RORC, RORB, RORA | AKR1C3 967/4885AKR1C2 900/4885LMNA 4342/4885 |
| US-11034654-B2 | 2,3-dihydroisoindole-1-carboxamides useful as ROR-gamma modulators | RORA, RORC, RORB | AKR1C3 2472/4885AKR1C2 2373/4885LMNA 4281/4885 |
| US-20200181084-A1 | NOVEL COMPOUNDS | RORC, RORB, RORA | AKR1C3 967/4885AKR1C2 900/4885LMNA 4342/4885 |
| US-20210380533-A1 | 2,3-DIHYDROISOINDOLE-1-CARBOXAMIDES USEFUL AS ROR-GAMMA MODULATORS | RORA, RORC, RORB | AKR1C3 2472/4885AKR1C2 2373/4885LMNA 4281/4885 |
| US-20190084934-A1 | NOVEL COMPOUNDS | RORC, RORB, RORA | AKR1C3 967/4885AKR1C2 900/4885LMNA 4342/4885 |
| US-20170166527-A1 | Novel Compounds | RORC, RORB, RORA | AKR1C3 967/4885AKR1C2 900/4885LMNA 4342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.