Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 7/20 | 0.48 |
| ▸ | METAP1 | P53582 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1896254 | 0.82 | ACP1 (0.49) | NPC1RAB9AGAAKDM4EMAPT | |
| SCHEMBL3006354 | 0.78 | GPR39 (0.45) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL27837532 | 0.74 | METAP2 (0.63) | METAP2METAP1LMNANPC1RAB9A | |
| SCHEMBL1898934 | 0.72 | JAK2 (0.48) | NPC1RAB9AGAAMAPK1 | |
| SCHEMBL28971995 | 0.68 | METAP2 (0.48) | METAP2METAP1LMNANPC1RAB9A | |
| SCHEMBL28972043 | 0.68 | METAP2 (0.48) | METAP2METAP1LMNANPC1RAB9A | |
| SCHEMBL28971994 | 0.68 | METAP2 (0.48) | METAP2METAP1LMNANPC1RAB9A | |
| SCHEMBL28967166 | 0.68 | METAP2 (0.48) | METAP2METAP1LMNANPC1RAB9A | |
| SCHEMBL28971964 | 0.68 | METAP2 (0.48) | METAP2METAP1LMNANPC1RAB9A | |
| SCHEMBL3007498 | 0.68 | ALDH1A1 (0.46) | LMNANPC1RAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493469-A2 | PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND | LG Life Sciences Ltd (KR) | 2012-09-05 | — | — | EP | claimed |
| US-20120214804-A1 | PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND | LG CHEM, LTD. (KR) | 2012-08-23 | — | — | US | claimed |
| WO-2011052950-A2 | PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND | LG LIFE SCIENCES LTD. (KR) | 2011-05-05 | — | — | WO | claimed |
| US-10322135-B2 | Pharmaceutical composition comprising indole compound | LG CHEM, LTD. (KR) | 2019-06-18 | — | — | US | disclosed |
| US-20170165272-A1 | PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND | LG LIFE SCIENCES LTD. (KR) | 2017-06-15 | — | — | US | disclosed |
| EP-2493469-A2 | PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND | LG Life Sciences Ltd (KR) | 2012-09-05 | — | — | EP | disclosed |
| US-20120214804-A1 | PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND | LG CHEM, LTD. (KR) | 2012-08-23 | — | — | US | disclosed |
| WO-2011052950-A2 | PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND | LG LIFE SCIENCES LTD. (KR) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214804-A1 | PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND | IDO1, IDO2, AIFM1 | METAP2 3234/4885METAP1 2823/4885LMNA 2337/4885 |
| US-10322135-B2 | Pharmaceutical composition comprising indole compound | IDO1, IDO2, AIFM1 | METAP2 3234/4885METAP1 2823/4885LMNA 2337/4885 |
| US-20170165272-A1 | PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND | TFAM, IDO1, AIFM1 | METAP2 3238/4885METAP1 2880/4885LMNA 1971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.