Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | BLM | P54132 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | AQP1 | P29972 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18993636 | 0.93 | ALDH1A1 (0.60) | ALDH1A1BLMKDM4EUSP2CA2 | |
| SCHEMBL21018922 | 0.88 | LMNA (0.50) | ALDH1A1BLMKDM4EUSP2CA2 | |
| SCHEMBL13283807 | 0.88 | ALDH1A1 (0.61) | ALDH1A1BLMKDM4EUSP2CA2 | |
| SCHEMBL19300124 | 0.84 | HPGD (0.61) | ALDH1A1BLMKDM4EUSP2CA2 | |
| SCHEMBL2741867 | 0.84 | KDM4E (0.72) | ALDH1A1BLMKDM4EUSP2CA2 | |
| SCHEMBL18993639 | 0.83 | KDM4E (0.60) | ALDH1A1BLMKDM4EUSP2CA2 | |
| SCHEMBL18993703 | 0.83 | KDM4E (0.60) | ALDH1A1BLMKDM4EUSP2CA2 | |
| SCHEMBL2741873 | 0.83 | CA2 (0.68) | ALDH1A1BLMKDM4EUSP2CA2 | |
| SCHEMBL2741865 | 0.82 | KDM4E (0.71) | ALDH1A1BLMKDM4EUSP2CA2 | |
| SCHEMBL2875002 | 0.82 | KDM4E (0.69) | ALDH1A1BLMKDM4EUSP2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190151263-A1 | BUMETANIDE ANALGOS, COMPOSITIONS, AND METHODS OF USE | NEUROPRO THERAPEUTICS INC (US) | 2019-05-23 | — | — | US | disclosed |
| US-9682928-B2 | Bumetanide analogs, compositions and methods of use | NEUROPRO THERAPEUTICS, INC. (US) | 2017-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151263-A1 | BUMETANIDE ANALGOS, COMPOSITIONS, AND METHODS OF USE | SLC6A1, SLC6A11, SLC6A13 | ALDH1A1 625/4885BLM 2912/4885KDM4E 2764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.