Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Demannose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL1326063 | 0.98 | LMNA (0.42) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Galactose SCHEMBL11013795 | 0.98 | LMNA (0.42) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL11016379 | 0.98 | LMNA (0.42) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL10954011 | 0.95 | LMNA (0.39) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL5394727 | 0.93 | LMNA (0.38) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Xylose SCHEMBL11015142 | 0.92 | LMNA (0.39) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Xylose SCHEMBL11015478 | 0.92 | LMNA (0.39) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL537703 | 0.90 | LMNA (0.50) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL329074 | 0.90 | LMNA (0.50) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Galactose SCHEMBL6900501 | 0.90 | LMNA (0.50) | LMNAL3MBTL1TDP1KDM4EPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9044411-B2 | Agent for keratinous fibers, comprising at least one acrylate/glyceryl acrylate copolymer, at least one film-forming and/or solidifying polymer and at least one ester oil | HENKEL AG & CO. KGAA (DE) | 2015-06-02 | — | — | US | disclosed |
| US-20140050686-A1 | AGENT FOR KERATINOUS FIBERS, COMPRISING AT LEAST ONE ACRYLATE/GLYCERYL ACRYLATE COPOLYMER, AT LEAST ONE FILM-FORMING AND/OR SOLIDIFYING POLYMER AND AT LEAST ONE ESTER OIL | HENKEL AG & CO. KGAA (DE) | 2014-02-20 | — | — | US | disclosed |
| US-8329152-B2 | Smooth styling agents | HENKEL AG & CO. KGAA (DE) | 2012-12-11 | — | — | US | disclosed |
| US-20120141406-A1 | AGENT FOR KERATINOUS FIBERS, COMPRISING AT LEAST ONE ACRYLATE/GLYCERYL ACRYLATE COPOLYMER, AT LEAST ONE FILM-FORMING AND/OR SOLIDIFYING POLYMER AND AT LEAST ONE ESTER OIL | HENKEL AG & CO. KGAA (DE) | 2012-06-07 | — | — | US | disclosed |
| US-20110110878-A1 | Smooth Styling Agents | HENKEL AG & CO. KGAA (DE) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110110878-A1 | Smooth Styling Agents | KRT18, PRKDC, TRPA1 | LMNA 437/4885L3MBTL1 4859/4885TDP1 2702/4885 |
| US-20140050686-A1 | AGENT FOR KERATINOUS FIBERS, COMPRISING AT LEAST ONE ACRYLATE/GLYCERYL ACRYLATE COPOLYMER, AT LEAST ONE FILM-FORMING AND/OR SOLIDIFYING POLYMER AND AT LEAST ONE ESTER OIL | KRT18, ACR, CUTA | LMNA 1305/4885L3MBTL1 4115/4885TDP1 2481/4885 |
| US-20120141406-A1 | AGENT FOR KERATINOUS FIBERS, COMPRISING AT LEAST ONE ACRYLATE/GLYCERYL ACRYLATE COPOLYMER, AT LEAST ONE FILM-FORMING AND/OR SOLIDIFYING POLYMER AND AT LEAST ONE ESTER OIL | KRT18, ACR, CUTA | LMNA 1305/4885L3MBTL1 4115/4885TDP1 2481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.