SCHEMBL1899765

SCHEMBL1899765

Nc1nc2c(ncn2-c2cccs2)c(=O)[nH]1

nearest known ligand 0.64

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
XDH P47989 9/20 0.64
MEN1 O00255 1/20 0.52
KMT2A Q03164 1/20 0.52
PNP P00491 5/20 0.50
NOS1 P29475 1/20 0.46
TK1 P04183 2/20 0.44
USP2 O75604 1/20 0.43
TSHR P16473 1/20 0.43
EDNRA P25101 1/20 0.43
HTR2A P28223 1/20 0.43
RECQL P46063 1/20 0.43
BLM P54132 1/20 0.43
HBB P68871 1/20 0.43
HSD17B10 Q99714 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2097438 0.78 XDH (0.55) XDHMEN1KMT2APNPTK1
SCHEMBL1286945 0.78 XDH (1.00) XDHMEN1KMT2APNPTK1
Hydrochloric Acid SCHEMBL21799342 0.77 XDH (0.97) XDHMEN1KMT2APNPTK1
SCHEMBL9798103 0.76 PNP (0.66) PNPTK1USP2TSHREDNRA
Hydrochloric Acid SCHEMBL17186373 0.75 PNP (0.65) PNPTK1USP2TSHREDNRA
SCHEMBL11610794 0.75 XDH (0.69) XDHMEN1KMT2APNPTK1
SCHEMBL27881952 0.74 XDH (0.76) XDHMEN1KMT2APNPTK1
SCHEMBL637360 0.74 XDH (0.67) XDHMEN1KMT2APNPTK1
Hydrochloric Acid SCHEMBL17186289 0.73 PNP (0.56) PNPTK1USP2TSHREDNRA
SCHEMBL3310025 0.73 XDH (0.76) XDHMEN1KMT2APNPTK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006096995-A1 SULFUR OLIGONUCLEOTIDES HAVING ANTIVIRAL ACTIVITIES REPLICOR INC. (CA) 2006-09-21 WO claimed
US-12031131-B2 RNA-editing oligonucleotides and uses thereof KORRO BIO, INC. (US) 2024-07-09 US disclosed
EP-4363574-A1 METHODS AND COMPOSITIONS FOR ADAR-MEDIATED EDITING Korro Bio, Inc. (US) 2024-05-08 EP disclosed
EP-4363575-A1 METHODS AND COMPOSITIONS FOR ADAR-MEDIATED EDITING Korro Bio, Inc. (US) 2024-05-08 EP disclosed
EP-4341405-A1 METHODS AND COMPOSITIONS FOR ADAR-MEDIATED EDITING Korro Bio, Inc. (US) 2024-03-27 EP disclosed
WO-2022256283-A9 METHODS FOR RESTORING PROTEIN FUNCTION USING ADAR KORRO BIO, INC. (US) 2023-12-28 WO disclosed
US-20230340464-A1 RNA-Editing Oligonucleotides and Uses Thereof KORRO BIO, INC. (US) 2023-10-26 US disclosed
US-20230332143-A1 RNA-Editing Oligonucleotides and Uses Thereof KORRO BIO, INC. (US) 2023-10-19 US disclosed
US-20230295614-A1 METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF ARGININOSUCCINATE LYASE (ASL) KORRO BIO, INC. 2023-09-21 US disclosed
US-20230295664-A1 METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF LEUCINE RICH REPEAT KINASE 2 (LRRK2) KORRO BIO, INC. 2023-09-21 US disclosed
US-20090197337-A1 Methods for the production of multimeric proteins and related compositions SEMBIOSYS GENETICS INC. (CA) 2009-08-06 US disclosed
WO-2006096995-A1 SULFUR OLIGONUCLEOTIDES HAVING ANTIVIRAL ACTIVITIES REPLICOR INC. (CA) 2006-09-21 WO disclosed
US-7098383-B2 Methods for the production of multimeric immunoglobulins, and related compositions SEMBIOSYS GENETICS INC. (CA) 2006-08-29 US disclosed
US-20060179514-A1 Methods for the production of multimeric protein complexes, and related compositions SEMBIOSYS GENETICS, INC. 2006-08-10 US disclosed
EP-1346056-A1 METHODS FOR THE PRODUCTION OF MULTIMERIC PROTEINS, AND RELATED COMPOSITIONS SemBioSys Genetics Inc. (CA) 2003-09-24 EP disclosed
US-20030167524-A1 Methods for the production of multimeric protein complexes, and related compositions SEMBIOSYS GENETICS, INC. (CA) 2003-09-04 US disclosed
US-20030093832-A1 Methods for the production of multimeric immunoglobulins, and related compositions SEMBIOSYS GENETICS INC. (CA) 2003-05-15 US disclosed
WO-2002050289-A9 METHODS FOR THE PRODUCTION OF MULTIMERIC PROTEINS, AND RELATED COMPOSITIONS SEMBIOSYS GENETICS INC (CA) 2003-04-17 WO disclosed
WO-2002050289-A1 METHODS FOR THE PRODUCTION OF MULTIMERIC PROTEINS, AND RELATED COMPOSITIONS SEMBIOSYS GENETICS, INC. (CA) 2002-06-27 WO disclosed
US-20020037303-A1 Thioredoxin and thioredoxin reductase containing oil body based products SEMBIOSYS GENETICS INC. (CA) 2002-03-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230332143-A1 RNA-Editing Oligonucleotides and Uses Thereof ADAR, NSUN3, NSUN2 XDH 815/4885MEN1 3538/4885KMT2A 1327/4885
US-20230295614-A1 METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF ARGININOSUCCINATE LYASE (ASL) ADAR, ADA, ASS1 XDH 428/4885MEN1 4641/4885KMT2A 1462/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.