Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | MASP2 | O00187 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902876 | 0.88 | BACE1 (0.40) | PDPK1MASP2BACE1HDAC1BACE2 | |
| SCHEMBL1903992 | 0.85 | NAMPT (0.42) | PDPK1MASP2KMT2AHDAC1 | |
| SCHEMBL1903417 | 0.84 | EPHX2 (0.43) | PDPK1 | |
| SCHEMBL1907783 | 0.83 | PDPK1 (0.38) | PDPK1MASP2BACE1KMT2AHDAC1 | |
| SCHEMBL1905788 | 0.83 | KLKB1 (0.42) | MAPTPDPK1TRPV1MASP2 | |
| SCHEMBL1901449 | 0.83 | KLKB1 (0.42) | MAPTPDPK1TRPV1MASP2 | |
| SCHEMBL1901316 | 0.82 | CA2 (0.40) | PDPK1TRPV1 | |
| SCHEMBL1431762 | 0.81 | MASP2 (0.43) | MASP2BACE1BACE2 | |
| SCHEMBL1902464 | 0.80 | MASP2 (0.39) | PDPK1MASP2BACE1 | |
| SCHEMBL1899812 | 0.80 | MASP2 (0.39) | PDPK1MASP2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |