Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 4/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1898934 | 0.93 | JAK2 (0.48) | PDE1APDE1BPDE1CJAK2JAK1 | |
| SCHEMBL1896254 | 0.84 | ACP1 (0.49) | GBA1NPC1GAARAB9ATNKS | |
| SCHEMBL29205591 | 0.69 | CSF1R (0.51) | ADORA2AADORA1JAK2JAK1TYK2 | |
| SCHEMBL1896774 | 0.68 | METAP2 (0.48) | NPC1GAARAB9A | |
| SCHEMBL27761849 | 0.65 | NPC1 (0.56) | ADORA3ADORA2AADORA2BADORA1NPC1 | |
| SCHEMBL17805439 | 0.65 | ADORA3 (0.42) | PDE1APDE1BPDE1CADORA3ADORA2A | |
| SCHEMBL3031910 | 0.65 | BRD4 (0.36) | PDE1APDE1BPDE1CPIM1PIM2 | |
| SCHEMBL31019203 | 0.65 | PDE10A (0.52) | PDE1APDE1BPDE1CADORA3ADORA2A | |
| SCHEMBL15102362 | 0.64 | IDH1 (0.62) | PDE1APDE1BPDE1CADORA3ADORA2A | |
| SCHEMBL1895948 | 0.64 | NPC1 (0.55) | ADORA3ADORA2AADORA1NPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10322135-B2 | Pharmaceutical composition comprising indole compound | LG CHEM, LTD. (KR) | 2019-06-18 | — | — | US | disclosed |
| US-20170165272-A1 | PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND | LG LIFE SCIENCES LTD. (KR) | 2017-06-15 | — | — | US | disclosed |
| EP-2493469-A2 | PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND | LG Life Sciences Ltd (KR) | 2012-09-05 | — | — | EP | disclosed |
| US-20120214804-A1 | PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND | LG CHEM, LTD. (KR) | 2012-08-23 | — | — | US | disclosed |
| CN-102596198-A | Pharmaceutical composition comprising indole compound | LG LIFE SCIENCES LTD | 2012-07-18 | — | — | CN | disclosed |
| WO-2011052950-A2 | PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND | LG LIFE SCIENCES LTD. (KR) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214804-A1 | PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND | IDO1, IDO2, AIFM1 | PDE1A 4380/4885PDE1B 4300/4885PDE1C 4361/4885 |
| US-10322135-B2 | Pharmaceutical composition comprising indole compound | IDO1, IDO2, AIFM1 | PDE1A 4380/4885PDE1B 4300/4885PDE1C 4361/4885 |
| US-20170165272-A1 | PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND | TFAM, IDO1, AIFM1 | PDE1A 4381/4885PDE1B 4434/4885PDE1C 4462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.