Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19019884 | 0.90 | MAPT (0.43) | MAPK1OPRL1GAATP53NPSR1 | |
| SCHEMBL19019870 | 0.88 | CHRNB2 (0.43) | MAPK1ALDH1A1TDP1HTTNPC1 | |
| SCHEMBL19061947 | 0.88 | P2RX7 (0.44) | MAPK1CTSBALDH1A1NPC1RAB9A | |
| SCHEMBL19019882 | 0.87 | TRPV6 (0.43) | MAPK1OPRL1ALDH1A1TDP1HTT | |
| SCHEMBL20917786 | 0.87 | ALOX15B (0.46) | MAPK1ALDH1A1SIGMAR1LMNAGAA | |
| SCHEMBL19061872 | 0.87 | MAPK1 (0.41) | MAPK1OPRL1ALDH1A1TDP1HTT | |
| SCHEMBL20917965 | 0.86 | MAPK1 (0.41) | MAPK1OPRL1ALDH1A1TDP1SIGMAR1 | |
| SCHEMBL22263137 | 0.84 | MAPK1 (0.50) | MAPK1ALDH1A1TDP1SIGMAR1NPC1 | |
| SCHEMBL19019922 | 0.82 | MAPK1 (0.50) | MAPK1OPRL1ALDH1A1TDP1HTT | |
| SCHEMBL19019923 | 0.82 | GAA (0.43) | CTSBALDH1A1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184514-A1 | AUTOPHAGY INHIBITORS | Deutsches Krebsforschungszentrum (DE) | 2017-06-28 | — | — | EP | disclosed |