Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | HTR1D | P28221 | 3/20 | 0.45 |
| ▸ | HTR1B | P28222 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21844836 | 0.89 | ACKR3 (0.51) | ACKR3PARP1HTR1AHTR1DHTR1B | |
| SCHEMBL20083976 | 0.82 | ACKR3 (0.49) | ACKR3PARP1HTR1AHTR1DHTR1B | |
| SCHEMBL15276859 | 0.81 | KMT2A (0.59) | HTR2BMEN1KMT2A | |
| SCHEMBL19157408 | 0.80 | MEN1 (0.51) | ACKR3HTR1AHTR1DHTR1BHTR2B | |
| SCHEMBL20083898 | 0.79 | KDR (0.44) | ACKR3HTR1AHTR1DHTR1BHTR2B | |
| SCHEMBL15076321 | 0.76 | HTR2B (0.51) | ACKR3HTR2BMEN1KMT2A | |
| SCHEMBL21844943 | 0.75 | ALDH1A1 (0.54) | ACKR3HTR1AHTR1DHTR1BHTR2B | |
| SCHEMBL21844944 | 0.75 | HTR1A (0.54) | ACKR3HTR1AHTR1DHTR1BMEN1 | |
| SCHEMBL20083956 | 0.74 | MCHR1 (0.53) | — | |
| SCHEMBL21844837 | 0.74 | HTR2A (0.47) | ACKR3HTR1AHTR1DHTR1BDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794565-B1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS INC (US) | 2017-07-26 | — | — | EP | disclosed |