Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | HTR1D | P28221 | 3/20 | 0.43 |
| ▸ | HTR1B | P28222 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 5/20 | 0.43 |
| ▸ | TERT | O14746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19157226 | 0.90 | HTR1A (0.41) | KDRHTR1DHTR1BHTR1AACKR3 | |
| SCHEMBL21844836 | 0.87 | ACKR3 (0.51) | HTR1DHTR1BHTR1AACKR3MEN1 | |
| SCHEMBL21844944 | 0.85 | HTR1A (0.54) | HTR1DHTR1BHTR1AACKR3MEN1 | |
| SCHEMBL21844837 | 0.84 | HTR2A (0.47) | HTR1DHTR1BHTR1AACKR3HTR2A | |
| SCHEMBL21844912 | 0.84 | MCHR1 (0.42) | ACKR3ROCK2 | |
| SCHEMBL21844945 | 0.83 | ACKR3 (0.53) | ACKR3MEN1KMT2A | |
| SCHEMBL21844943 | 0.81 | ALDH1A1 (0.54) | HTR1DHTR1BHTR1AACKR3MEN1 | |
| SCHEMBL20083956 | 0.80 | MCHR1 (0.53) | KDR | |
| SCHEMBL15276936 | 0.79 | KMT2A (0.59) | MEN1KMT2A | |
| SCHEMBL19157261 | 0.79 | ACKR3 (0.49) | HTR1DHTR1BHTR1AACKR3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312160-B1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS INC (US) | 2020-03-18 | — | — | EP | disclosed |
| EP-3312160-A1 | HEPATITIS B ANTIVIRAL AGENTS | Novira Therapeutics Inc. (US) | 2018-04-25 | — | — | EP | disclosed |