Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.68 |
| ▸ | KDM1A | O60341 | 4/20 | 0.68 |
| ▸ | DRD2 | P14416 | 4/20 | 0.68 |
| ▸ | HTR1A | P08908 | 3/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.68 |
| ▸ | DRD1 | P21728 | 3/20 | 0.68 |
| ▸ | DRD5 | P21918 | 3/20 | 0.68 |
| ▸ | HRH1 | P35367 | 3/20 | 0.68 |
| ▸ | DRD3 | P35462 | 3/20 | 0.68 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.68 |
| ▸ | PRNP | P04156 | 2/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.68 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.68 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.68 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.68 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19196333 | 0.85 | SIGMAR1 (0.74) | SIGMAR1CYP1A2CYP2D6KDM1ADRD2 | |
| Promazine SCHEMBL9052694 | 0.82 | CYP2D6 (1.00) | SIGMAR1CYP1A2CYP2D6KDM1ADRD2 | |
| Promazine SCHEMBL29392545 | 0.82 | CYP2D6 (1.00) | SIGMAR1CYP1A2CYP2D6KDM1ADRD2 | |
| Promazine SCHEMBL140489 | 0.82 | CYP2D6 (1.00) | SIGMAR1CYP1A2CYP2D6KDM1ADRD2 | |
| SCHEMBL6866302 | 0.81 | SIGMAR1 (0.68) | SIGMAR1CYP1A2CYP2D6KDM1ADRD2 | |
| SCHEMBL5880420 | 0.81 | ITGB2 (0.73) | SIGMAR1CYP1A2CYP2D6KDM1ADRD2 | |
| Promazine SCHEMBL123418 | 0.80 | LMNA (1.00) | SIGMAR1CYP1A2CYP2D6KDM1ADRD2 | |
| Promazine SCHEMBL29390978 | 0.80 | LMNA (1.00) | SIGMAR1CYP1A2CYP2D6KDM1ADRD2 | |
| Promazine SCHEMBL27425063 | 0.80 | CYP2D6 (0.97) | SIGMAR1CYP1A2CYP2D6KDM1ADRD2 | |
| Promazine SCHEMBL27429489 | 0.80 | CYP2D6 (0.97) | SIGMAR1CYP1A2CYP2D6KDM1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10940150-B2 | Thymine derivatives and quinazoline-dione derivatives for the inhibition of HSP27 | TECHNISCHE UNIVERSITAET DRESDEN (DE) | 2021-03-09 | — | — | US | disclosed |
| US-20180207160-A1 | THYMINE DERIVATIVES AND QUINAZOLINE-DIONE DERIVATIVES FOR THE INHIBITION OF HSP27 | TECHNISCHE UNIVERSITAET DRESDEN (DE) | 2018-07-26 | — | — | US | disclosed |
| US-20170216297-A1 | EFFICIENT INHIBITION OF HSP27 | TECHNISCHE UNIVERSITAET DRESDEN (DE) | 2017-08-03 | — | — | US | disclosed |
| US-20170216297-A1 | EFFICIENT INHIBITION OF HSP27 | TECHNISCHE UNIVERSITAET DRESDEN (DE) | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180207160-A1 | THYMINE DERIVATIVES AND QUINAZOLINE-DIONE DERIVATIVES FOR THE INHIBITION OF HSP27 | HSPB1, HSP90B1, HSP90AB1 | SIGMAR1 2552/4885CYP1A2 3282/4885CYP2D6 3442/4885 |
| US-20170216297-A1 | EFFICIENT INHIBITION OF HSP27 | HSPB1, HSP90AB2P, HSP90B1 | SIGMAR1 2165/4885CYP1A2 2264/4885CYP2D6 3842/4885 |
| US-10940150-B2 | Thymine derivatives and quinazoline-dione derivatives for the inhibition of HSP27 | HSPB1, HSP90B1, HSP90AB1 | SIGMAR1 2552/4885CYP1A2 3282/4885CYP2D6 3442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.