Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18922367 | 0.90 | POLB (0.49) | TSHRPOLBLMNAALDH1A1L3MBTL1 | |
| SCHEMBL8379974 | 0.86 | L3MBTL1 (0.48) | TSHRPOLBLMNAALDH1A1L3MBTL1 | |
| SCHEMBL21567963 | 0.85 | KDM4E (0.46) | TSHRPOLBLMNAALDH1A1L3MBTL1 | |
| SCHEMBL19728850 | 0.84 | L3MBTL1 (0.48) | POLBALDH1A1L3MBTL1HPGDSMN1; SMN2 | |
| SCHEMBL19200801 | 0.83 | L3MBTL1 (0.43) | TSHRPOLBLMNAALDH1A1L3MBTL1 | |
| SCHEMBL4193078 | 0.83 | L3MBTL1 (0.46) | TSHRPOLBLMNAALDH1A1L3MBTL1 | |
| SCHEMBL24339478 | 0.82 | L3MBTL1 (0.50) | POLBALDH1A1L3MBTL1HPGDHTT | |
| SCHEMBL20112946 | 0.82 | RAB9A (0.56) | TSHRPOLBLMNAALDH1A1L3MBTL1 | |
| SCHEMBL23119558 | 0.81 | POLB (0.47) | TSHRPOLBLMNAALDH1A1L3MBTL1 | |
| SCHEMBL5527414 | 0.81 | L3MBTL1 (0.47) | TSHRPOLBLMNAALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12016835-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2024-06-25 | — | — | US | disclosed |
| US-20230285340-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2023-09-14 | — | — | US | disclosed |
| US-11571426-B2 | Compositions for preventing or treating lupus | CHONG KUN DANG PHARMACEUTICAL CORP. | 2023-02-07 | — | — | US | disclosed |
| US-11547687-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-01-10 | — | — | US | disclosed |
| US-20210059966-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2021-03-04 | — | — | US | disclosed |
| US-20200368245-A1 | COMPOSITIONS FOR PREVENTING OR TREATING LUPUS | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2020-11-26 | — | — | US | disclosed |
| US-10172858-B2 | Combination pharmaceutical compositions and uses thereof | INTELLIKINE LLC (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180118705-A1 | PROCESS FOR PREPARING 4-AMINO-5-BIPHENYL-4-YL-2-HYDROXYMETHYL-2-METHYL-PENTANOIC ACID COMPOUND | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2018-05-03 | — | — | US | disclosed |
| US-20170216252-A1 | ANTI-BACTERIAL PYRUVATE KINASE MODULATOR COMPOUNDS, COMPOSITIONS, USES AND METHODS | SIMON FRASER UNIVERSITY (CA) | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230285340-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | TSHR 1031/4885POLB 1844/4885LMNA 553/4885 |
| US-11547687-B2 | Neprilysin inhibitors | MME, REN, ACE | TSHR 1031/4885POLB 1844/4885LMNA 553/4885 |
| US-11571426-B2 | Compositions for preventing or treating lupus | SSB, TLR9, TLR5 | TSHR 3279/4885POLB 3661/4885LMNA 115/4885 |
| US-20180118705-A1 | PROCESS FOR PREPARING 4-AMINO-5-BIPHENYL-4-YL-2-HYDROXYMETHYL-2-METHYL-PENTANOIC ACID COMPOUND | CYP4B1, P2RX5, P2RX6 | TSHR 1935/4885POLB 1371/4885LMNA 1758/4885 |
| US-20170216252-A1 | ANTI-BACTERIAL PYRUVATE KINASE MODULATOR COMPOUNDS, COMPOSITIONS, USES AND METHODS | PDK1, PDK3, PDK2 | TSHR 3492/4885POLB 844/4885LMNA 2835/4885 |
| US-20200368245-A1 | COMPOSITIONS FOR PREVENTING OR TREATING LUPUS | SSB, TLR9, TLR5 | TSHR 3279/4885POLB 3661/4885LMNA 115/4885 |
| US-20210059966-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | TSHR 1031/4885POLB 1844/4885LMNA 553/4885 |
| US-10172858-B2 | Combination pharmaceutical compositions and uses thereof | CDC25C, CCNC, CDC25B | TSHR 4341/4885POLB 313/4885LMNA 1699/4885 |
| US-12016835-B2 | Neprilysin inhibitors | MME, REN, ACE | TSHR 1031/4885POLB 1844/4885LMNA 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.