Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.42 |
| ▸ | HTR3B | O95264 | 3/20 | 0.42 |
| ▸ | HTR3A | P46098 | 3/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | HTR5A | P47898 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1920629 | 0.75 | CYP3A4 (0.45) | HTR1AHTR1DHTR1BHTR3EHTR3B | |
| SCHEMBL3056753 | 0.73 | HTR5A (0.43) | HTR1AHTR1DHTR1BHTR3EHTR3B | |
| SCHEMBL28499890 | 0.68 | HTR3E (0.49) | HTR1AHTR1DHTR1BHTR3EHTR3B | |
| SCHEMBL4977907 | 0.67 | HTR3E (0.59) | HTR1AHTR1DHTR1BHTR3EHTR3B | |
| SCHEMBL9396666 | 0.67 | HTR3E (0.51) | HTR1AHTR1DHTR1BHTR3EHTR3B | |
| SCHEMBL7369557 | 0.65 | HTR3E (0.49) | HTR1AHTR1DHTR1BHTR3EHTR3B | |
| SCHEMBL4543250 | 0.65 | ADRB1 (0.62) | HTR1AHTR1DHTR1BHTR3EHTR3B | |
| SCHEMBL6964245 | 0.65 | ADRB1 (0.65) | HTR1AHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8705185 | 0.64 | HTR1A (0.49) | HTR1AHTR1DHTR1BHTR3EHTR3B | |
| SCHEMBL12004436 | 0.64 | HTR3E (0.54) | HTR1AHTR1DHTR1BHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326666-A1 | NEUROPEPTIDE-2 RECEPTOR (Y-2R) AGONISTS AND USES THEREOF | F. Hoffmann-La Roche AG (CH) | 2011-06-01 | — | — | EP | claimed |
| WO-2010031707-A1 | NEUROPEPTIDE-2 RECEPTOR (Y-2R) AGONISTS AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-25 | — | — | WO | claimed |