SCHEMBL1924971

SCHEMBL1924971

c1cc2ccc1CNCc1ccc(cc1)C2

nearest known ligand 0.39

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
APEX1 P27695 2/20 0.39
TERT O14746 1/20 0.33
CHKA P35790 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL179204 0.73 APEX1 (0.64) APEX1TERTCHKA
SCHEMBL4946987 0.71 CHKA (0.38) APEX1TERTCHKA
SCHEMBL1103773 0.65 APEX1 (0.43) APEX1TERT
SCHEMBL19089065 0.65 APEX1 (0.42) APEX1TERTCHKA
SCHEMBL21955684 0.65 APEX1 (0.42) APEX1TERTCHKA
SCHEMBL16627792 0.64 OXTR (0.40) APEX1
SCHEMBL15267971 0.62 APEX1 (0.40) APEX1TERT
SCHEMBL329861 0.58 HTR2C (0.38)
SCHEMBL10612 0.55
SCHEMBL13590042 0.55 PNMT (0.65)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210355265-A1 TRANSPARENT TPU BLENDS WITH PYRROLIDONE-CONTAINING POLYAMIDES BASF SE (DE) 2021-11-18 US claimed
EP-3494153-B1 TRANSPARENT TPU BLENDS WITH PYRROLIDONE CONTAINING POLYAMIDES BASF SE (DE) 2020-09-09 EP claimed
US-10745557-B2 Polyamide mixtures comprising polyamides containing pyrrolidone BASF SE (DE) 2020-08-18 US claimed
EP-3420017-B1 POLYAMIDE BLENDS HAVING POLYAMIDES CONTAINING PYRROLIDONE BASF SE (DE) 2019-12-18 EP claimed
US-20190048189-A1 POLYAMIDE MIXTURES COMPRISING POLYAMIDES CONTAINING PYRROLIDONE BASF SE (DE) 2019-02-14 US claimed
US-20210355265-A1 TRANSPARENT TPU BLENDS WITH PYRROLIDONE-CONTAINING POLYAMIDES BASF SE (DE) 2021-11-18 US disclosed
US-10745557-B2 Polyamide mixtures comprising polyamides containing pyrrolidone BASF SE (DE) 2020-08-18 US disclosed
US-20190048189-A1 POLYAMIDE MIXTURES COMPRISING POLYAMIDES CONTAINING PYRROLIDONE BASF SE (DE) 2019-02-14 US disclosed
EP-1767520-B1 Hydrogenation of aromatic amines to alicyclic amines using a ruthenium catalyst supported on lithium aluminate AIR PROD & CHEM (US) 2011-06-08 EP disclosed
US-7465833-B2 Hydrogenation of aromatic amines to alicyclic amines using a lithium aluminate-based catalyst AIR PRODUCTS AND CHEMICALS, INC. (US) 2008-12-16 US disclosed
US-20080146768-A1 PROCESSES FOR PREPARING POLYMERS USING ALPHA,OMEGA-DIFUNCTIONAL ALDARAMIDES E. I. DU PONT DE NEMOURS AND COMPANY 2008-06-19 US disclosed
EP-1858955-A1 PROCESSES USING ALPHA, OMEGA-DIFUNCTIONAL ALDARAMIDES AS MONOMERS AND CROSSLINKERS E.I. DUPONT DE NEMOURS AND COMPANY (US) 2007-11-28 EP disclosed
EP-1767520-A1 Hydrogenation of aromatic amines to alicyclic amines using a ruthenium catalyst supported on lithium aluminate Air Products and Chemicals, Inc. (US) 2007-03-28 EP disclosed
US-20070066849-A1 Hydrogenation of aromatic amines to alicyclic amines using a lithium aluminate-based catalyst EVONIK OPERATIONS GMBH (DE) 2007-03-22 US disclosed
US-20060264672-A1 Processes using alpha, omega-difunctional aldaramides as monomers and crosslinkers E. I. DU PONT DE NEMOURS AND COMPANY 2006-11-23 US disclosed
WO-2006091901-A1 PROCESSES USING ALPHA, OMEGA-DIFUNCTIONAL ALDARAMIDES AS MONOMERS AND CROSSLINKERS E.I. DUPONT DE NEMOURS AND COMPANY (US) 2006-08-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060264672-A1 Processes using alpha, omega-difunctional aldaramides as monomers and crosslinkers ALOX5, GSTO1, FASN APEX1 624/4885TERT 855/4885CHKA 405/4885
US-20070066849-A1 Hydrogenation of aromatic amines to alicyclic amines using a lithium aluminate-based catalyst HRH3, HRH4, AAAS APEX1 618/4885TERT 1174/4885CHKA 744/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.