SCHEMBL19253255

SCHEMBL19253255

C=C(C)C(=O)Nc1ccc(Cl)cc1C(=O)c1ccccc1

nearest known ligand 0.68

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.64
ALDH1A1 P00352 3/20 0.62
LMNA P02545 2/20 0.62
SMN1; SMN2 Q16637 4/20 0.60
TP53 P04637 4/20 0.60
CYP1A2 P05177 2/20 0.57
CYP3A4 P08684 2/20 0.57
CYP2C9 P11712 2/20 0.57
CYP2C19 P33261 2/20 0.57
SERPINE1 P05121 1/20 0.56
GAA P10253 2/20 0.55
THRB P10828 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30661117 1.00 MAPT (0.64) MAPTALDH1A1LMNASMN1; SMN2TP53
SCHEMBL22386325 0.89 MAPT (0.67) MAPTALDH1A1LMNASMN1; SMN2TP53
SCHEMBL19268087 0.88 TP53 (0.54) MAPTALDH1A1LMNASMN1; SMN2TP53
SCHEMBL11827090 0.86 MAPT (0.72) MAPTALDH1A1LMNASMN1; SMN2TP53
SCHEMBL31000396 0.86 MAPT (0.72) MAPTALDH1A1LMNASMN1; SMN2TP53
SCHEMBL19268075 0.85 GABRP (0.63) MAPTALDH1A1LMNASMN1; SMN2TP53
SCHEMBL12683507 0.85 MAPT (0.62) MAPTALDH1A1LMNASMN1; SMN2TP53
SCHEMBL19268086 0.85 ALDH1A1 (0.59) MAPTALDH1A1LMNASMN1; SMN2CYP1A2
SCHEMBL3044265 0.84 KDM4E (0.71) ALDH1A1TP53SERPINE1GAA
SCHEMBL9790112 0.84 MAPT (0.64) MAPTALDH1A1LMNASMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12595368-B2 UV/HEVL-filtering contact lenses ALCON INC. (CH) 2026-04-07 US disclosed
EP-4529621-A1 UV/HEVL-FILTERING CONTACT LENSES Alcon Inc. (CH) 2025-04-02 EP disclosed
CN-112189004-B Process for preparing keto-functionalized aromatic (meth) acrylated products 赢创运营有限公司 2023-12-15 CN disclosed
WO-2023228055-A1 UV/HEVL-FILTERING CONTACT LENSES ALCON INC. (CH) 2023-11-30 WO disclosed
US-20230374306-A1 UV/HEVL-FILTERING CONTACT LENSES ALCON INC. (CH) 2023-11-23 US disclosed
US-11505520-B2 Method for preparing keto-functionalized aromatic (meth)acrylates EVONIK OPERATIONS GMBH (DE) 2022-11-22 US disclosed
US-20210214297-A1 METHOD FOR PREPARING KETO-FUNCTIONALIZED AROMATIC (METH)ACRYLATES EVONIK OPERATIONS GMBH (DE) 2021-07-15 US disclosed
US-20210214297-A1 METHOD FOR PREPARING KETO-FUNCTIONALIZED AROMATIC (METH)ACRYLATES EVONIK OPERATIONS GMBH (DE) 2021-07-15 US disclosed
CN-112189004-A Method for producing keto-functionalized aromatic (meth) acrylates 赢创运营有限公司 2021-01-05 CN disclosed
EP-3652139-B1 METHOD FOR PREPARING KETO-FUNCTIONALIZED AROMATIC (METH)ACRYLATES EVONIK OPERATIONS GMBH (DE) 2020-09-23 EP disclosed
EP-3419961-B1 UV/VISIBLE-ABSORBING VINYLIC MONOMERS AND USES THEREOF ALCON INC (CH) 2020-09-02 EP disclosed
EP-3652139-A1 METHOD FOR PREPARING KETO-FUNCTIONALIZED AROMATIC (METH)ACRYLATES Evonik Operations GmbH (DE) 2020-05-20 EP disclosed
US-10268053-B2 UV/visible-absorbing vinylic monomers and uses thereof NOVARTIS AG (CH) 2019-04-23 US disclosed
US-10268053-B2 UV/visible-absorbing vinylic monomers and uses thereof NOVARTIS AG (CH) 2019-04-23 US disclosed
EP-3419961-A1 UV/VISIBLE-ABSORBING VINYLIC MONOMERS AND USES THEREOF Novartis AG (CH) 2019-01-02 EP disclosed
WO-2017145022-A1 UV/VISIBLE-ABSORBING VINYLIC MONOMERS AND USES THEREOF NOVARTIS AG (CH) 2017-08-31 WO disclosed
WO-2017145022-A1 UV/VISIBLE-ABSORBING VINYLIC MONOMERS AND USES THEREOF NOVARTIS AG (CH) 2017-08-31 WO disclosed
US-20170242274-A1 UV/VISIBLE-ABSORBING VINYLIC MONOMERS AND USES THEREOF ALCON INC. (CH) 2017-08-24 US disclosed
US-20170242274-A1 UV/VISIBLE-ABSORBING VINYLIC MONOMERS AND USES THEREOF ALCON INC. (CH) 2017-08-24 US disclosed
US-20170242274-A1 UV/VISIBLE-ABSORBING VINYLIC MONOMERS AND USES THEREOF ALCON INC. (CH) 2017-08-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11505520-B2 Method for preparing keto-functionalized aromatic (meth)acrylates ALKBH3, ALKBH5, ACR MAPT 1067/4885ALDH1A1 229/4885LMNA 2868/4885
US-10268053-B2 UV/visible-absorbing vinylic monomers and uses thereof VCL, UACA, XRCC6 MAPT 132/4885ALDH1A1 547/4885LMNA 729/4885
US-12595368-B2 UV/HEVL-filtering contact lenses UACA, HSPA4L, RAD54L MAPT 453/4885ALDH1A1 1073/4885LMNA 2948/4885
US-20210214297-A1 METHOD FOR PREPARING KETO-FUNCTIONALIZED AROMATIC (METH)ACRYLATES ALKBH3, ALKBH5, ACR MAPT 1067/4885ALDH1A1 229/4885LMNA 2868/4885
US-20170242274-A1 UV/VISIBLE-ABSORBING VINYLIC MONOMERS AND USES THEREOF VCL, UACA, XRCC6 MAPT 132/4885ALDH1A1 547/4885LMNA 729/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.