SCHEMBL19285690

SCHEMBL19285690

COc1cc(C(C)F)c(OC)cc1CC(C)N

nearest known ligand 0.76

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 6/20 0.69
TAAR1 Q96RJ0 3/20 0.65
HTR1A P08908 2/20 0.61
HTR2C P28335 2/20 0.61
HTR2B P41595 2/20 0.61
CYP1A2 P05177 1/20 0.61
CYP3A4 P08684 1/20 0.61
CYP2D6 P10635 1/20 0.61
TSHR P16473 1/20 0.61
NFKB1 P19838 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30797769 0.86 HTR2A (0.73) HTR2ATAAR1HTR1AHTR2CHTR2B
SCHEMBL30855258 0.86 TAAR1 (0.51) HTR2ATAAR1HTR1AHTR2CHTR2B
SCHEMBL398580 0.82 HTR2A (1.00) HTR2ATAAR1HTR1AHTR2CHTR2B
SCHEMBL29425260 0.82 HTR2A (1.00) HTR2ATAAR1HTR1AHTR2CHTR2B
SCHEMBL398581 0.82 HTR2A (1.00) HTR2ATAAR1HTR1AHTR2CHTR2B
SCHEMBL5305859 0.82 TAAR1 (0.68) HTR2ATAAR1HTR1AHTR2CHTR2B
SCHEMBL5305857 0.82 TAAR1 (0.68) HTR2ATAAR1HTR1AHTR2CHTR2B
SCHEMBL26064983 0.81 HTR2A (0.76) HTR2ATAAR1HTR1AHTR2CHTR2B
SCHEMBL5308097 0.80 HTR2A (0.81) HTR2ATAAR1HTR1AHTR2CHTR2B
SCHEMBL5308098 0.80 HTR2A (0.81) HTR2ATAAR1HTR1AHTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12534428-B2 Non-distillative process for manufacturing high purity amphetamines Pharmapotheca A, Inc. (US) 2026-01-27 US disclosed
US-20250213502-A1 Amphetamine Controlled Release, Prodrug, and Abuse-deterrent Dosage Forms Pharmapotheca A, Inc. 2025-07-03 US disclosed
US-12208068-B2 Amphetamine controlled release, prodrug, and abuse-deterrent dosage forms Pharmapotheca A Inc. (US) 2025-01-28 US disclosed
US-20240286993-A1 Non-distillative Process for Manufacturing High Purity Amphetamines Pharmapotheca A, Inc. 2024-08-29 US disclosed
US-20230321010-A1 Amphetamine Controlled Release, Prodrug, and Abuse-deterrent Dosage Forms CHEMAPOTHECA, LLC (US) 2023-10-12 US disclosed
US-11717498-B2 Methods of treatment using amphetamine controlled release, prodrug, and abuse deterrent dosage forms Pharmapotheca A, Inc. (US) 2023-08-08 US disclosed
US-11123310-B2 Amphetamine controlled release, prodrug, and abuse-deterrent dosage forms PHARMAPOTHECA, LLC (US) 2021-09-21 US disclosed
US-20210030699-A1 Methods of Treatment Using Amphetamine Controlled Release, Prodrug, and Abuse Deterrent Dosage Forms PHARMAPOTHECA, LLC (US) 2021-02-04 US disclosed
US-20200352883-A1 METHODS OF TREATMENT USING AMPHETAMINE CONTROLLED RELEASE, PRODRUG, AND ABUSE-DETERRENT DOSAGE FORMS CHEMAPOTHECA, LLC (US) 2020-11-12 US disclosed
EP-3478363-A1 AMPHETAMINE CONTROLLED RELEASE, PRODRUG, AND ABUSE DETERRENT DOSAGE FORMS Chemapotheca LLC (US) 2019-05-08 EP disclosed
US-20180243241-A1 AMPHETAMINE CONTROLLED RELEASE, PRODRUG, AND ABUSE-DETERRENT DOSAGE FORMS CHEMAPOTHECA, LLC 2018-08-30 US disclosed
WO-2017147375-A1 AMPHETAMINE CONTROLLED RELEASE, PRODRUG, AND ABUSE DETERRENT DOSAGE FORMS CHEMAPOTHECA, LLC (US) 2017-08-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11123310-B2 Amphetamine controlled release, prodrug, and abuse-deterrent dosage forms SLC6A3, CES2, SLC6A2 HTR2A 138/4885TAAR1 52/4885HTR1A 197/4885
US-11717498-B2 Methods of treatment using amphetamine controlled release, prodrug, and abuse deterrent dosage forms SLC6A3, SLC6A2, CES2 HTR2A 95/4885TAAR1 51/4885HTR1A 150/4885
US-20240286993-A1 Non-distillative Process for Manufacturing High Purity Amphetamines AASDHPPT, AADAT, SLC6A3 HTR2A 549/4885TAAR1 133/4885HTR1A 534/4885
US-20200352883-A1 METHODS OF TREATMENT USING AMPHETAMINE CONTROLLED RELEASE, PRODRUG, AND ABUSE-DETERRENT DOSAGE FORMS SLC6A3, SLC6A2, CES2 HTR2A 93/4885TAAR1 40/4885HTR1A 142/4885
US-20230321010-A1 Amphetamine Controlled Release, Prodrug, and Abuse-deterrent Dosage Forms SLC6A3, CES2, SLC6A2 HTR2A 143/4885TAAR1 37/4885HTR1A 209/4885
US-12534428-B2 Non-distillative process for manufacturing high purity amphetamines SMS, SRMS, SRM HTR2A 118/4885TAAR1 28/4885HTR1A 84/4885
US-20210030699-A1 Methods of Treatment Using Amphetamine Controlled Release, Prodrug, and Abuse Deterrent Dosage Forms SLC6A3, SLC6A2, CES2 HTR2A 95/4885TAAR1 51/4885HTR1A 150/4885
US-12208068-B2 Amphetamine controlled release, prodrug, and abuse-deterrent dosage forms SLC6A3, CES2, SLC6A2 HTR2A 143/4885TAAR1 37/4885HTR1A 209/4885
US-20250213502-A1 Amphetamine Controlled Release, Prodrug, and Abuse-deterrent Dosage Forms SLC6A3, CES2, SLC6A2 HTR2A 138/4885TAAR1 52/4885HTR1A 197/4885
US-20180243241-A1 AMPHETAMINE CONTROLLED RELEASE, PRODRUG, AND ABUSE-DETERRENT DOSAGE FORMS SLC6A3, CES2, SLC6A2 HTR2A 138/4885TAAR1 52/4885HTR1A 197/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.