Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | NT5E | P21589 | 2/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL309069 | 1.00 | ESR2 (0.55) | ESR2PTPN1TAAR1FFAR1CETP | |
| SCHEMBL5443082 | 0.81 | ALOX5 (0.47) | ESR2PTPN1TAAR1FFAR1PDK2 | |
| SCHEMBL12534388 | 0.81 | PTPN5 (0.45) | PDK2HSD17B1HSD17B2APPPTPN5 | |
| SCHEMBL12628146 | 0.81 | KIF11 (0.46) | CYP3A4APPPTPN5 | |
| SCHEMBL4497165 | 0.81 | KIF11 (0.46) | CYP3A4APPPTPN5 | |
| SCHEMBL24720988 | 0.80 | PTPN5 (0.57) | CYP3A4APPPTPN5 | |
| SCHEMBL2420728 | 0.80 | CES2 (0.49) | PTPN1CETPAPP | |
| SCHEMBL12534332 | 0.79 | PRKCI (0.50) | FFAR1CETPPDK2APPPTPN5 | |
| SCHEMBL1931183 | 0.78 | FFAR1 (0.49) | FFAR1CYP17A1CYP3A4 | |
| SCHEMBL5456164 | 0.78 | PTPN5 (0.55) | PDK2PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450532-B2 | Compounds useful in the preparation of tryptophan hydroxylase inhibitors | LEXICON PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450532-B2 | Compounds useful in the preparation of tryptophan hydroxylase inhibitors | LEXICON PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450532-B2 | Compounds useful in the preparation of tryptophan hydroxylase inhibitors | LEXICON PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-20110130564-A1 | COMPOUNDS USEFUL IN THE PREPARATION OF TRYPTOPHAN HYDRROXYLASE INHIBITORS | TERSERA THERAPEUTICS LLC | 2011-06-02 | — | — | US | disclosed |
| US-20110130564-A1 | COMPOUNDS USEFUL IN THE PREPARATION OF TRYPTOPHAN HYDRROXYLASE INHIBITORS | TERSERA THERAPEUTICS LLC | 2011-06-02 | — | — | US | disclosed |
| US-20110130564-A1 | COMPOUNDS USEFUL IN THE PREPARATION OF TRYPTOPHAN HYDRROXYLASE INHIBITORS | TERSERA THERAPEUTICS LLC | 2011-06-02 | — | — | US | disclosed |
| US-7897763-B2 | Process for the preparation of substituted phenylalanines | LEXICON PHARMACEUTICALS, INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-7897763-B2 | Process for the preparation of substituted phenylalanines | LEXICON PHARMACEUTICALS, INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-7897763-B2 | Process for the preparation of substituted phenylalanines | LEXICON PHARMACEUTICALS, INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-7855291-B2 | Process for the preparation of substituted phenylalanines | LEXICON PHARMACEUTICALS, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-20090118505-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES | TERSERA THERAPEUTICS LLC | 2009-05-07 | — | — | US | disclosed |
| US-20090118505-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES | TERSERA THERAPEUTICS LLC | 2009-05-07 | — | — | US | disclosed |
| US-20090118505-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES | TERSERA THERAPEUTICS LLC | 2009-05-07 | — | — | US | disclosed |
| US-20090099206-A1 | SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL-4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOIC ACID AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| US-20090099206-A1 | SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL-4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOIC ACID AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| US-20090099206-A1 | SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL-4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOIC ACID AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| WO-2009048864-A1 | SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL-4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOIC ACID AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| US-20090048280-A1 | Process for the preparation of substituted phenylalanines | TERSERA THERAPEUTICS LLC | 2009-02-19 | — | — | US | disclosed |
| US-20090048280-A1 | Process for the preparation of substituted phenylalanines | TERSERA THERAPEUTICS LLC | 2009-02-19 | — | — | US | disclosed |
| US-20090048280-A1 | Process for the preparation of substituted phenylalanines | TERSERA THERAPEUTICS LLC | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130564-A1 | COMPOUNDS USEFUL IN THE PREPARATION OF TRYPTOPHAN HYDRROXYLASE INHIBITORS | TPH1, TPH2, PAH | ESR2 4526/4885PTPN1 3831/4885TAAR1 666/4885 |
| US-20090099206-A1 | SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL-4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOIC ACID AND METHODS OF THEIR USE | PCCA, ANXA6, CPS1 | ESR2 1361/4885PTPN1 2616/4885TAAR1 1351/4885 |
| US-20090118505-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES | PAH, TYR, NPEPPS | ESR2 4138/4885PTPN1 2622/4885TAAR1 455/4885 |
| US-20090048280-A1 | Process for the preparation of substituted phenylalanines | PAH, TYR, NPEPPS | ESR2 4138/4885PTPN1 2622/4885TAAR1 455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.