Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | MERTK | Q12866 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 4/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | HCK | P08631 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365744 | 0.88 | ABL1 (0.43) | ALDH1A1MAPTSMN1; SMN2JAK2ABL1 | |
| SCHEMBL19670359 | 0.88 | CLK2 (0.40) | CLK2LRRK2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL19365640 | 0.87 | MLLT1 (0.37) | TRPV3ALDH1A1MAPTSMN1; SMN2JAK2 | |
| SCHEMBL19364877 | 0.87 | TRPV3 (0.38) | TRPV3ALDH1A1MAPTSMN1; SMN2JAK2 | |
| SCHEMBL17618496 | 0.85 | CLK2 (0.39) | CLK2LRRK2IRAK4TRPV3HCRTR2 | |
| SCHEMBL19365269 | 0.84 | KARS1 (0.45) | IRAK4TRPV3SMN1; SMN2JAK2ABL1 | |
| SCHEMBL19365415 | 0.84 | BRAF (0.41) | CNR1CNR2WNT1GSK3BDYRK1A | |
| SCHEMBL19670153 | 0.84 | VCP (0.41) | TRPV3JAK2CNR2GSK3BDYRK1A | |
| SCHEMBL19670365 | 0.83 | VCP (0.37) | TRPV3HCRTR2JAK2CNR1ABL1 | |
| SCHEMBL19670423 | 0.83 | TRPV3 (0.38) | TRPV3ALDH1A1JAK2ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |